{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:32:09Z","timestamp":1782257529098,"version":"3.54.5"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,30]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Breast cancers have broad histological subtypes with varied molecular expression, which determines the management. Although ductal and lobular breast carcinomas constitute the significant 90% of these tumours, other subtypes constitute about 10% of breast cancers. Adenoid cystic carcinoma (AdCC) is a salivary gland-type tumour described in breast, constituting less than 1% of all breast carcinomas. These tumours have a favourable prognosis and are surgically managed by either lumpectomy or mastectomy. Solid-basaloid and AdCC with high-grade transformation are the sporadic subtypes of AdCC, in addition to the classic type. We report a case of recurrent AdCC which was surgically managed by modified radical mastectomy initially and presented with recurrence and high-grade transformation 11\u2009years later.<\/jats:p>","DOI":"10.1136\/bcr-2022-252336","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T10:05:20Z","timestamp":1675937120000},"page":"e252336","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Adenoid cystic carcinoma of the breast with late recurrence and high-grade transformation"],"prefix":"10.1136","volume":"16","author":[{"given":"Gowtham","family":"Vasudevan","sequence":"first","affiliation":[{"name":"General Surgery, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Mary","family":"John","sequence":"additional","affiliation":[{"name":"Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaykumar","family":"D K","sequence":"additional","affiliation":[{"name":"Breast Clinic and Surgical Oncology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana George","family":"Vallonthaiel","sequence":"additional","affiliation":[{"name":"Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"2025082708594269000_16.2.e252336.1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-8693-z"},{"key":"2025082708594269000_16.2.e252336.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199904000-00012"},{"key":"2025082708594269000_16.2.e252336.3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12105-013-0458-8","article-title":"\u201cdedifferentiation\u201d and high-grade transformation in salivary gland carcinomas","volume":"7","author":"Nagao","year":"2013","journal-title":"Head and Neck Pathol"},{"key":"2025082708594269000_16.2.e252336.4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s12105-019-01120-3","article-title":"Adenoid cystic carcinoma with transformation to high grade carcinomatous and sarcomatoid components: a rare case report with review of literature","volume":"14","author":"Dutta","year":"2020","journal-title":"Head Neck Pathol"},{"key":"2025082708594269000_16.2.e252336.5","unstructured":"WHO Classification of Tumours Editorial Board . 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