{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:35Z","timestamp":1756425815042,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,23]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Malignant mesothelioma is a rare aggressive tumour of the mesothelium with a propensity to spread locally and, rarely, to distant organs. The latest advances in its diagnosis and treatment have led to an increase in unusual disease presentations. Although a direct invasion of the perineum has been previously described in a men, a malignant mesothelioma spreading to the perianal region was never reported in a women. We presented a rare case of malignant mesothelioma recurrence spreading from the peritoneal cavity to the perineum through the rectovaginal space.<\/jats:p>","DOI":"10.1136\/bcr-2022-252441","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:25:20Z","timestamp":1676373920000},"page":"e252441","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rare recurrence of malignant mesothelioma spreading to the perineum"],"prefix":"10.1136","volume":"16","author":[{"given":"Angelo Alessandro","family":"Marra","sequence":"first","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-0037","authenticated-orcid":false,"given":"Carlo","family":"Ratto","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Department of Medical and Surgical Sciences, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"2025082801390282000_16.2.e252441.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"2025082801390282000_16.2.e252441.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21572"},{"key":"2025082801390282000_16.2.e252441.3","first-page":"659","article-title":"Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives","volume":"31","author":"Boussios","year":"2018","journal-title":"Ann Gastroenterol"},{"key":"2025082801390282000_16.2.e252441.4","doi-asserted-by":"publisher","DOI":"10.1200\/JC0.2017.76.6394"},{"key":"2025082801390282000_16.2.e252441.5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.21037\/tlcr-19-620","article-title":"Update on the pathologic diagnosis of malignant mesothelioma","volume":"9","author":"Schulte","year":"2020","journal-title":"Transl Lung Cancer Res"},{"key":"2025082801390282000_16.2.e252441.6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.lungcan.2012.03.021","article-title":"Perineal and colonic metastases in two cases of malignant mesothelioma","volume":"77","author":"Grewal","year":"2012","journal-title":"Lung Cancer"},{"key":"2025082801390282000_16.2.e252441.7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00192-015-2878-3","article-title":"Concepts of the rectovaginal septum: implications for function and surgery","volume":"27","author":"Dariane","year":"2016","journal-title":"Int Urogynecol J"},{"key":"2025082801390282000_16.2.e252441.8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/carcin\/bgy018","article-title":"Fgf2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a mapkinase\/MMP1 signal","volume":"39","author":"Schelch","year":"2018","journal-title":"Carcinogenesis"},{"key":"2025082801390282000_16.2.e252441.9","first-page":"1593","article-title":"A rare case of primary malignant mesothelioma originating from the rectovaginal tissue","volume":"45","author":"Shimoyama","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"2025082801390282000_16.2.e252441.10","first-page":"1715","article-title":"Combination therapy Approved for adults with mesothelioma","volume":"324","author":"Voelker","year":"2020","journal-title":"JAMA"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:39:09Z","timestamp":1756370349000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,14]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/bcr-2022-252441"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252441","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}