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In line with this, pirfenidone may exert pleiotropic therapeutic effects in other immune-mediated diseases such as psoriasis, while, at the same time, spare immunosuppression-related side effects of current antipsoriatic drugs. Pirfenidone-mediated enhanced absorption of ultraviolet A and ultraviolet B by skin keratinocytes might represent a potential mechanism. The possible role of pirfenidone as an antipsoriatic drug requires large-scale and long-term study.<\/jats:p>","DOI":"10.1136\/bcr-2022-252591","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T22:45:32Z","timestamp":1695854732000},"page":"e252591","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Improvement of psoriatic skin lesions following pirfenidone use in patients with fibrotic lung disease"],"prefix":"10.1136","volume":"16","author":[{"given":"Theodoros","family":"Karampitsakos","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-7149","authenticated-orcid":false,"given":"Vasilina","family":"Sotiropoulou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthaios","family":"Katsaras","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-6292","authenticated-orcid":false,"given":"Argyrios","family":"Tzouvelekis","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"2025082708030527000_16.9.e252591.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2012.00302.x"},{"key":"2025082708030527000_16.9.e252591.2","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02046-2018","article-title":"Pirfenidone in the kaleidoscope: reflecting mechanisms through different angles","volume":"52","author":"Tzouvelekis","year":"2018","journal-title":"Eur Respir J"},{"key":"2025082708030527000_16.9.e252591.3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00026-2015"},{"key":"2025082708030527000_16.9.e252591.4","doi-asserted-by":"crossref","unstructured":"Tzouvelekis A , Karampitsakos T , Ntolios P , et al . n.d. \u201cLongitudinal \"real-world\" outcomes of Pirfenidone in idiopathic pulmonary fibrosis in Greece\u201d. 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