{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:40:05Z","timestamp":1756309205548,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,12,16]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                  <jats:italic>Goodpasture syndrome<\/jats:italic> is a rare autoimmune disease which affects young adults with a male preponderance and can be triggered at any point in life with a classical clinical triad of rapidly progressive glomerulonephritis, diffuse pulmonary haemorrhage and circulating anti-glomerular basement membrane antibody (anti-GBM antibody). Here we are presenting a case of a young man with hypertension in his early 20s who presented with fatigue, recurrent haemoptysis, breathlessness and decreased urine output without features of infection. He was diagnosed at an early stage of the disease with the help of clinical, serological and radiological findings. An early diagnosis with effective treatment using plasma exchange, intravenous high-dose methylprednisolone, and cyclophosphamide showed a rapid improvement in the patient\u2019s condition with an immediate decrease in anti-GBM titres and proteinuria.<\/jats:p>","DOI":"10.1136\/bcr-2022-252666","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:17:47Z","timestamp":1704845867000},"page":"e252666","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Goodpasture syndrome: a rare case presenting with recurrent haemoptysis"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-1240","authenticated-orcid":false,"given":"Sai Shankar","family":"Mankuzhy Gopalakrishnan","sequence":"first","affiliation":[{"name":"Radiodiagnosis, Shri Sathya Sai Medical College and Research Institute, Chengalpattu, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remya","family":"Raveendran","sequence":"additional","affiliation":[{"name":"Radiodiagnosis, Shri Sathya Sai Medical College and Research Institute, Chengalpattu, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenikar","family":"Paulraj","sequence":"additional","affiliation":[{"name":"Radiodiagnosis, Shri Sathya Sai Medical College and Research Institute, Chengalpattu, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshavardhan","family":"Balaganesan","sequence":"additional","affiliation":[{"name":"Radiodiagnosis, Shri Sathya Sai Medical College and Research Institute, Chengalpattu, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"2025082708102740000_17.1.e252666.1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ki.2012.375","article-title":"Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease","volume":"83","author":"Tang","year":"2013","journal-title":"Kidney Int"},{"key":"2025082708102740000_17.1.e252666.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6516.301"},{"key":"2025082708102740000_17.1.e252666.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.07.019"},{"key":"2025082708102740000_17.1.e252666.4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.nima.2014.01.052","article-title":"Investigation of unique total ionizing dose effects in 0.2 \u03bcm partially-depleted silicon-on-insulator technology","volume":"745","author":"Zhang","year":"2014","journal-title":"Nucl Instrum Methods Phys Res"},{"key":"2025082708102740000_17.1.e252666.5","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20327"},{"key":"2025082708102740000_17.1.e252666.6","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199407000-00001"},{"key":"2025082708102740000_17.1.e252666.7","doi-asserted-by":"crossref","unstructured":"Charney DI , Border WA . Goodpasture\u2019s syndrome. In: Suki WN , Massry SG , eds. Therapy of Renal Diseases and Related Disorders. Springer, 1998: 401\u201311. doi:10.1007\/978-1-4757-6632-5","DOI":"10.1007\/978-1-4757-6632-5_22"},{"key":"2025082708102740000_17.1.e252666.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.10.007"},{"key":"2025082708102740000_17.1.e252666.9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.495"},{"key":"2025082708102740000_17.1.e252666.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.04.007"},{"key":"2025082708102740000_17.1.e252666.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0320ST"},{"key":"2025082708102740000_17.1.e252666.12","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.2.7839958"},{"key":"2025082708102740000_17.1.e252666.13","first-page":"674","article-title":"Roentgenographic aspects of the hemorrhagic pulmonary-renal disease (Goodpasture\u2019s syndrome)","volume":"94","author":"SYBERS","year":"1965","journal-title":"Am J Roentgenol Radium Ther Nucl Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:32Z","timestamp":1756307432000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1136\/bcr-2022-252666"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252666","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}