{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:07:51Z","timestamp":1772590071040,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,12,22]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Granular cell tumours (GCTs) are benign tumours that rarely develop in intraocular regions. We report a rare case of intraocular GCT in the ciliary body. A woman in her 20s with a history of bone marrow transplantation for malignant lymphoma in early childhood was referred to our department for bilateral proliferative diabetic retinopathy. A yellowish-white ciliary tumour was observed in the temporal periphery of the patient\u2019s left eye during routine ophthalmological examination. As the tumour enlarged, we performed total resection combined with vitrectomy, silicone oil tamponade and cataract surgery. Histopathological examination revealed tumour cells with small, round or oval nuclei with eosinophilic cytoplasm. Positive immunohistochemical staining for S-100 and vimentin led to a diagnosis of ciliary GCT. No retinal detachment, proliferative membrane formation or tumour recurrence was observed 4\u2009years postoperatively. Intraocular GCT should be considered a differential diagnosis of ciliary tumours.<\/jats:p>","DOI":"10.1136\/bcr-2022-252691","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:16:14Z","timestamp":1672312574000},"page":"e252691","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Granular cell tumour in the ciliary body"],"prefix":"10.1136","volume":"15","author":[{"given":"Yoshiharu","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jichi Ika Daigaku Fuzoku Saitama Iryo Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-6148","authenticated-orcid":false,"given":"Toshikatsu","family":"Kaburaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jichi Ika Daigaku Fuzoku Saitama Iryo Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kakehashi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jichi Ika Daigaku Fuzoku Saitama Iryo Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-2045","authenticated-orcid":false,"given":"Shigenobu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmic Oncology, Kokuritsu Gan Kenkyu Center Kenkyujo, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"2025082713201066000_15.12.e252691.1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00428-015-1877-6","article-title":"Solitary, multiple, benign, atypical, or malignant: the \"Granular Cell Tumor\" puzzle","volume":"468","author":"Machado","year":"2016","journal-title":"Virchows Arch"},{"key":"2025082713201066000_15.12.e252691.2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90033-6"},{"key":"2025082713201066000_15.12.e252691.3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/eye.2015.268","article-title":"Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review","volume":"30","author":"Li","year":"2016","journal-title":"Eye"},{"key":"2025082713201066000_15.12.e252691.4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/IOP.0000000000002038","article-title":"Granular cell tumor of the orbit: review of the literature and a proposed treatment modality","volume":"38","author":"Barrantes","year":"2022","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025082713201066000_15.12.e252691.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00598611"},{"key":"2025082713201066000_15.12.e252691.6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/01676830.2017.1337181","article-title":"Progressive orbital granular cell tumour associated with medial rectus","volume":"36","author":"Yang","year":"2017","journal-title":"Orbit"},{"key":"2025082713201066000_15.12.e252691.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70838-4"},{"key":"2025082713201066000_15.12.e252691.8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1755-3768.2009.01655.x","article-title":"Granular cell tumour of the lacrimal gland","volume":"87","author":"von Holstein","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"2025082713201066000_15.12.e252691.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00380-8"},{"key":"2025082713201066000_15.12.e252691.10","first-page":"106","article-title":"Granular cell tumor of the eyelid","volume":"23","author":"Bregman","year":"1991","journal-title":"Ann Ophthalmol"},{"key":"2025082713201066000_15.12.e252691.11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90180-X"},{"key":"2025082713201066000_15.12.e252691.12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.083790"},{"key":"2025082713201066000_15.12.e252691.13","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.50.2.99"},{"key":"2025082713201066000_15.12.e252691.14","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-021-02219-4","article-title":"Retinal granular cell tumor: a case report","volume":"21","author":"Park","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"2025082713201066000_15.12.e252691.15","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-019-1102-5","article-title":"Granular cell tumor presenting as an intraocular mass: a case report","volume":"19","author":"Yang","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"2025082713201066000_15.12.e252691.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02078314"},{"key":"2025082713201066000_15.12.e252691.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90462-1"},{"key":"2025082713201066000_15.12.e252691.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00135-9"},{"key":"2025082713201066000_15.12.e252691.19","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1948.00900030017002"},{"key":"2025082713201066000_15.12.e252691.20","first-page":"517","article-title":"Granular cell myoblastoma","volume":"42","author":"Powell","year":"1946","journal-title":"Arch Pathol"},{"key":"2025082713201066000_15.12.e252691.21","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200207000-00031"},{"key":"2025082713201066000_15.12.e252691.22","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1067\/mjd.2002.108492","article-title":"Multiple cutaneous granular cell tumors in a child in remission for Hodgkin's disease","volume":"47","author":"De Raeve","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"2025082713201066000_15.12.e252691.23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.747"},{"key":"2025082713201066000_15.12.e252691.24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00129"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:20:18Z","timestamp":1756326018000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,29]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bcr-2022-252691"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252691","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}