{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:10:06Z","timestamp":1756321806543,"version":"3.44.0"},"reference-count":38,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,13]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>We report the case of a woman in her 50s who underwent, 5\u2009years prior, a total gastrectomy after neoadjuvant chemotherapy for diffuse-type gastric cancer diagnosed during a workup for isolated gastric primary light chain (AL) amyloidosis. At the time of diagnosis, immunoglobulins light chain measurements and bone marrow biopsy were performed to rule out multiple myeloma and came back normal. Three years later, the patient developed systemic amyloidosis involving the heart and the lungs, after which she developed multiple myeloma. Isolated amyloid deposits in the stomach are a rare finding. While AL amyloidosis is frequently found in concomitance with multiple myeloma, late progression of primary AL amyloidosis to systemic amyloidosis and multiple myeloma is uncommon.<\/jats:p>","DOI":"10.1136\/bcr-2022-252786","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:05:27Z","timestamp":1685354727000},"page":"e252786","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple myeloma"],"prefix":"10.1136","volume":"16","author":[{"given":"Georges","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint John Hospital, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Fiani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universite Saint-Joseph Faculte de medecine, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-7276","authenticated-orcid":false,"given":"Fares","family":"Antaki","sequence":"additional","affiliation":[{"name":"Ophthalmology, Centre Hospitalier Universitaire de l'Universite de Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-6596","authenticated-orcid":false,"given":"Ernest","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Universite Saint-Joseph Faculte de medecine, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"2025082711525602000_16.5.e252786.1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2020.1835263"},{"key":"2025082711525602000_16.5.e252786.2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12269"},{"key":"2025082711525602000_16.5.e252786.3","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12677"},{"key":"2025082711525602000_16.5.e252786.4","first-page":"670","article-title":"Amylo\u00efdose Gastrique pseudo Tumorale: a Propos D\u2019Une observation rare","volume":"88","author":"Nfoussi","year":"2010","journal-title":"Amylo\u00efdose Gastrique Pseudo Tumorale Propos Une Obs Rare"},{"key":"2025082711525602000_16.5.e252786.5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.068155"},{"key":"2025082711525602000_16.5.e252786.6","unstructured":"Endoscopic and biopsy findings of the upper digestive tract in patients with Amyloidosis [ScienceDirect]. Available: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0016510790709133 [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.7","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.59"},{"key":"2025082711525602000_16.5.e252786.8","unstructured":"Localized primary Amyloidosis of the stomach presenting with gastric hemorrhage - BJ\u00f6RNSSON - 1987 - Acta Medica Scandinavica. Wiley Online Library. Available: https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.0954-6820.1987.tb01252.x [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000489297","article-title":"Gastroparesis in a patient with gastric AL Amyloidosis","volume":"12","author":"Hoscheit","year":"2018","journal-title":"Case Rep Gastroenterol"},{"key":"2025082711525602000_16.5.e252786.10","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.3748\/wjg.v9.i11.2632","article-title":"A case report of localized gastric Amyloidosis","volume":"9","author":"Wu","year":"2003","journal-title":"World J Gastroenterol"},{"key":"2025082711525602000_16.5.e252786.11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.15403\/jgld-3088","article-title":"Localized gastric Amyloidosis","volume":"29","author":"Furukawa","year":"2020","journal-title":"J Gastrointestin Liver Dis"},{"key":"2025082711525602000_16.5.e252786.12","unstructured":"Primary gastric Amyloidosis presenting as an isolated gastric mass - gastrointestinal endoscopy. Available: https:\/\/www.giejournal.org\/article\/S0016-5107(12)00225-8\/fulltext [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12328-016-0651-x","article-title":"Localized Amyloidosis of the stomach mimicking a superficial gastric cancer","volume":"9","author":"Kagawa","year":"2016","journal-title":"Clin J Gastroenterol"},{"key":"2025082711525602000_16.5.e252786.14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5946\/ce.2017.118","article-title":"Localized gastric Amyloidosis with Kappa and Lambda light chain co-expression","volume":"51","author":"Ahn","year":"2018","journal-title":"Clin Endosc"},{"key":"2025082711525602000_16.5.e252786.15","unstructured":"El-Nakeep S , Kasi A . Linitis Plastica. Treasure Island (FL): StatPearls Publishing, 2021."},{"key":"2025082711525602000_16.5.e252786.16","doi-asserted-by":"crossref","DOI":"10.1186\/s12957-017-1187-3","article-title":"The significance of a nineteenth century definition in the era of Genomics: Linitis Plastica","volume":"15","author":"Agnes","year":"2017","journal-title":"World J Surg Oncol"},{"key":"2025082711525602000_16.5.e252786.17","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-16-1-29"},{"key":"2025082711525602000_16.5.e252786.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04422-7"},{"key":"2025082711525602000_16.5.e252786.19","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.lpm.2007.03.004","article-title":"Linite Plastique Gastrique","volume":"36","author":"Issam Beyrouti","year":"2007","journal-title":"La Presse M\u00e9dicale"},{"key":"2025082711525602000_16.5.e252786.20","unstructured":"Amylose Gastrique Simulant une Linite Plastique. \u00c0 Propos D\u2019Une observation rare [ScienceDirect]. Available: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003394406000034 [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.21","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1055\/s-0028-1119470","article-title":"Amyloid tumor of the stomach simulating an obstructing gastric carcinoma: case report and review of the literature","volume":"41 Suppl 2","author":"Losanoff","year":"2009","journal-title":"Endoscopy"},{"key":"2025082711525602000_16.5.e252786.22","doi-asserted-by":"crossref","unstructured":"Singh V , Singla S , Singh H , et al . Massive Hematemesis in a case of gastric Amyloidosis masquerading as gastric carcinoma. Autops Case Rep 2019;9. doi:10.4322\/acr.2018.074","DOI":"10.4322\/acr.2018.074"},{"key":"2025082711525602000_16.5.e252786.23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/s-0028-1098263","article-title":"A case of Amyloid tumor of the stomach","volume":"10","author":"Ikeda","year":"1978","journal-title":"Endoscopy"},{"key":"2025082711525602000_16.5.e252786.24","unstructured":"Gastric outlet obstruction due to gastric Amyloidosis mimicking malignancy in a patient with Ankylosing Spondylitis. Available: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3856268\/ [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/1097-0142(196903)23:3<576::AID-CNCR2820230308>3.0.CO;2-Y","article-title":"Pleomorphic lymphoma and gastric adenocarcinoma (collision Neoplasm) associated with Monoclonal Macroglobulinemia and Amyloidosis: a case report","volume":"23","author":"Coppola","year":"1969","journal-title":"Cancer"},{"key":"2025082711525602000_16.5.e252786.26","unstructured":"Massive hemorrhage and pseudo-obstruction of the small intestine caused by primary AL Amyloidosis associated with gastric cancer: report of a case [SpringerLink]. Available: https:\/\/link.springer.com\/article\/10.1007\/s00595-004-2805-6 [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.27","unstructured":"EBSCOhost . Isolated gastric Amyloidoma in the setting of marginal zone MALT lymphoma: case report and review of the literature | 95869431. Available: https:\/\/eds.s.ebscohost.com\/abstract?site=eds&scope=site&jrnl=00106178&AN=95869431&h=e9R1PUi6RmyjpuzlNzQnVjRs0gjog8VlEsgRKB7s2JKwasA08CcLWp5YRE5WlhACNtL5tnaJppRRBlYzmZJMGA%3d%3d&crl=c&resultLocal=ErrCrlNoResults&resultNs=Ehost&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d00106178%26AN%3d95869431 [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.28","first-page":"85","article-title":"Primary Linitis Plastica of the right colon","volume":"101","author":"Onorati","year":"2009","journal-title":"Pathologica"},{"key":"2025082711525602000_16.5.e252786.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5584.99"},{"key":"2025082711525602000_16.5.e252786.30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980415)82:8<1501::AID-CNCR11>3.0.CO;2-8"},{"key":"2025082711525602000_16.5.e252786.31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/13506129.2018.1443439","article-title":"Bone marrow plasma cell infiltration in light chain Amyloidosis: impact on organ involvement and outcome","volume":"25","author":"Tovar","year":"2018","journal-title":"Amyloid"},{"key":"2025082711525602000_16.5.e252786.32","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"2025082711525602000_16.5.e252786.33","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20381"},{"key":"2025082711525602000_16.5.e252786.34","unstructured":"How to image cardiac Amyloidosis: a practical approach [ScienceDirect]. Available: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1936878X19307132 [Accessed 07 Nov 2021]."},{"key":"2025082711525602000_16.5.e252786.35","doi-asserted-by":"publisher","DOI":"10.1177\/003335491112600403"},{"key":"2025082711525602000_16.5.e252786.36","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.amjcard.2019.08.045","article-title":"Increasing rate of hospital admissions in patients with Amyloidosis (from the National inpatient sample)","volume":"124","author":"Sperry","year":"2019","journal-title":"Am J Cardiol"},{"key":"2025082711525602000_16.5.e252786.37","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/13506129.2015.1102131","article-title":"The patient\u2019s perspective on the symptom and everyday life impact of AL Amyloidosis","volume":"22","author":"Lin","year":"2015","journal-title":"Amyloid"},{"key":"2025082711525602000_16.5.e252786.38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2147\/JBM.S183857","article-title":"Treatment options for relapsed\/refractory systemic light-chain (AL) Amyloidosis: current perspectives","volume":"10","author":"Sarosiek","year":"2019","journal-title":"J Blood Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:53:07Z","timestamp":1756320787000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,29]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/bcr-2022-252786"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252786","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}