{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:49:58Z","timestamp":1767905398654,"version":"3.49.0"},"reference-count":10,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,1]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune neuroinflammatory disorder of the central nervous system that very rarely may be a paraneoplastic phenomenon. We describe the case of a woman with a longitudinally extensive transverse myelitis (LETM). We identified a previously undiagnosed, follicular lymphoma and she was treated with the immunochemotherapy regime (obinutuzumab, cyclophosphamide, vincristine and prednisolone; O-CVP) for paraneoplastic NMOSD. Following two cycles, there was almost complete radiological remission of the myelitis and the patient showed some improvement in her neurological function. This case illustrates the heterogeneous aetiology that LETM may have and that O-CVP may be used as therapeutic option in patients with NMOSD driven by follicular lymphoma.<\/jats:p>","DOI":"10.1136\/bcr-2022-252822","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:36:11Z","timestamp":1668512171000},"page":"e252822","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel approach using O-CVP to treat paraneoplastic NMO spectrum disorder associated with follicular lymphoma"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-995X","authenticated-orcid":false,"given":"David Antony","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Haematology, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menelaos","family":"Pipis","sequence":"additional","affiliation":[{"name":"Department of Haematology, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-3034","authenticated-orcid":false,"given":"Piers","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Haematology, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Silber","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2025082723522923000_15.11.e252822.1","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1177\/1352458517731914","article-title":"Clinical profile of patients with paraneoplastic neuromyelitis optica spectrum disorder and aquaporin-4 antibodies","volume":"24","author":"Sep\u00falveda","year":"2018","journal-title":"Mult Scler"},{"key":"2025082723522923000_15.11.e252822.2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001014"},{"key":"2025082723522923000_15.11.e252822.3","doi-asserted-by":"crossref","unstructured":"Pittock SJ , Lennon VA . Aquaporin-4 autoantibodies in a paraneoplastic context. Arch Neurol 2008;65.doi:10.1001\/archneur.65.5.629","DOI":"10.1001\/archneur.65.5.629"},{"key":"2025082723522923000_15.11.e252822.4","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.leukres.2011.02.019","article-title":"A paraneoplastic neuromyelitis optica spectrum disorder associated with a mature B-cell neoplasm","volume":"35","author":"Nakayama-Ichiyama","year":"2011","journal-title":"Leuk Res"},{"key":"2025082723522923000_15.11.e252822.5","unstructured":"Wang SS , Lau TK . Paraneoplastic neuromyelitis optica spectrum disorder diagnosed with mantle cell lymphoma. 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