{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:40:03Z","timestamp":1756305603670,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,22]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Flecainide is a class 1C antiarrhythmic and is highly effective for treating a wide range of arrhythmias. It is not licensed for children under the age of 12 years, but has been used safely for years in young children, particularly when first-line agents are not effective. Although toxicity does occur in both adult and paediatric populations, there have been very few reported instances of flecainide toxicity in neonates and children. Supratherapeutic levels of flecainide manifests on ECG with prolongation of the PR interval, QRS duration and QT, and can lead to life-threatening arrhythmias. In milk-fed infants receiving flecainide, regular feeding patterns are paramount to achieve a steady therapeutic state, as milk and dairy products are known to reduce the absorption of flecainide. This case series details four milk-fed infants admitted with ECG changes secondary to flecainide toxicity.<\/jats:p>","DOI":"10.1136\/bcr-2022-252823","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:22:23Z","timestamp":1675333343000},"page":"e252823","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Flecainide toxicity: ECG changes associated with supratherapeutic levels in milk-fed infants"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-5107","authenticated-orcid":false,"given":"Hitarth","family":"Bhatt","sequence":"first","affiliation":[{"name":"Paediatric Cardiology, Evelina London Children's Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Will","family":"Regan","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology, Evelina London Children's Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology, Evelina London Children's Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Bellsham-Revell","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology, Evelina London Children's Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"2025082707175147000_16.2.e252823.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.62.2.133"},{"key":"2025082707175147000_16.2.e252823.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103213241201"},{"key":"2025082707175147000_16.2.e252823.3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0140-6736(89)90504-7","article-title":"Use of flecainide in children","volume":"2","author":"Till","year":"1989","journal-title":"Lancet"},{"key":"2025082707175147000_16.2.e252823.4","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut082"},{"key":"2025082707175147000_16.2.e252823.5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jce.12335","article-title":"Brugada phenocopy with a flecainide overdose: a pharmacological dose effect?","volume":"25","author":"Chubb","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2025082707175147000_16.2.e252823.6","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-2608","article-title":"Complete heart block secondary to flecainide toxicity: is it time for CYP2D6 genotype testing?","volume":"146","author":"Poh","year":"2020","journal-title":"Pediatrics"},{"key":"2025082707175147000_16.2.e252823.7","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/oxfordjournals.eurheartj.a062445","article-title":"Experience with flecainide for the treatment of cardiac arrhythmias in children","volume":"9","author":"Priestley","year":"1988","journal-title":"Eur Heart J"},{"key":"2025082707175147000_16.2.e252823.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.6.860"},{"key":"2025082707175147000_16.2.e252823.9","doi-asserted-by":"crossref","unstructured":"Thompson B , Mangat J , Barton C , et al . Decreased milk drinking causing flecainide toxicity in an older child. 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Flecainide toxicity secondary to accidental overdose: a pediatric case report of two brothers. Case Rep Crit Care 2021;2021. doi:10.1155\/2021\/6633859","DOI":"10.1155\/2021\/6633859"},{"key":"2025082707175147000_16.2.e252823.17","unstructured":"Medicines for Children . Flecainide for arrhythmias: information for parents and carers. 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