{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:10:21Z","timestamp":1756282221086,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,31]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Haemoglobin E (HbE) affects at least 1 million people around the world. The carrier frequency of HbE\/beta-thalassaemia (HbE\/\u03b2-thalassaemia) is highest in Southeast Asia. In India, the highest frequency is observed in the northeast region. Distinguishing between homozygous HbE disease and HbE\/\u03b2-thalassaemia is a challenge to the haematopathologist as well as to the treating obstetrician because both are clinically and haematologically similar, posing a difficulty in managing anaemia and assessing the fetal risk for the same disease. This article reports a case of compound heterozygote HbE\/\u03b2-thalassaemia in pregnancy and its successful outcome.<\/jats:p>","DOI":"10.1136\/bcr-2022-252829","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T12:11:19Z","timestamp":1675771879000},"page":"e252829","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Successful outcome in a compound heterozygote haemoglobin E\/beta-thalassaemia in pregnancy"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-2424","authenticated-orcid":false,"given":"Kalika","family":"Dubey","sequence":"first","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-2502","authenticated-orcid":false,"given":"Charu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suma","family":"Shet","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2025082700373340000_16.2.e252829.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08054.x"},{"key":"2025082700373340000_16.2.e252829.2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0974-2727.180793","article-title":"Hemoglobin E hemoglobinopathy in an adult from Assam with unusual presentation: a diagnostic dilemma","volume":"8","author":"Kiran","year":"2016","journal-title":"J Lab Physicians"},{"key":"2025082700373340000_16.2.e252829.3","doi-asserted-by":"crossref","unstructured":"Keohane EM , Otto CN , Walenga JM . Thalassemias. In: Rodak\u2019s Hematology. Sixth Edition. Louis (MO): Elsevier, 2020: 424\u201344. 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New York: Mc Graw Hill, 2022."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:37:46Z","timestamp":1756280266000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,7]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/bcr-2022-252829"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252829","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}