{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:45:50Z","timestamp":1761677150825,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,21]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>A euthyroid woman in her 50s with papillary thyroid cancer and primary hyperparathyroidism was referred to our hospital for surgery. Her surgery was scheduled for 4 months later but was postponed because she was diagnosed with COVID-19. Five months after the first visit, she was admitted to our hospital to undergo the planned thyroid lobectomy and parathyroidectomy. Her blood tests on admission showed thyrotoxicosis, with negative thyroid-stimulating hormone receptor and thyroid-stimulating antibody. Notably, her anti-thyroglobulin antibody and anti-thyroid peroxidase antibody, which were originally negative, became positive after SARS-CoV-2 infection. She was diagnosed with painless thyroiditis. Her general condition and vital signs were stable, and the surgery was cautiously performed. Histopathological examination of the resected thyroid revealed papillary thyroid carcinoma, and the findings were consistent with painless thyroiditis. Her postoperative course was uneventful, and her thyroid function improved 2 weeks after the operation.<\/jats:p>","DOI":"10.1136\/bcr-2022-252837","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:55:19Z","timestamp":1669902919000},"page":"e252837","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Painless thyroiditis incidentally diagnosed following SARS-CoV-2 infection"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-4925","authenticated-orcid":false,"given":"Nobuhiko","family":"Nakaizumi","sequence":"first","affiliation":[{"name":"Internal Medicine, Kuma Hospital, Kobe, Hyogo-ken, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Fukata","sequence":"additional","affiliation":[{"name":"Internal Medicine, Kuma Hospital, Kobe, Hyogo-ken, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo-ken, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Akamizu","sequence":"additional","affiliation":[{"name":"Internal Medicine, Kuma Hospital, Kobe, Hyogo-ken, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2025082711555066000_15.12.e252837.1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.707726","article-title":"COVID-19-Associated subacute thyroiditis: evidence-based data from a systematic review","volume":"12","author":"Trimboli","year":"2021","journal-title":"Front Endocrinol"},{"key":"2025082711555066000_15.12.e252837.2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2022.102314","article-title":"Systematic review of COVID-19 and autoimmune thyroiditis","volume":"47","author":"Tutal","year":"2022","journal-title":"Travel Med Infect Dis"},{"key":"2025082711555066000_15.12.e252837.3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.endinu.2020.09.001","article-title":"Painless thyroiditis in SARS-CoV-2 infection","volume":"68","author":"Barahona San Mill\u00e1n","year":"2020","journal-title":"Endocrinol Diabetes Nutr"},{"key":"2025082711555066000_15.12.e252837.4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1507\/endocrj.EJ20-0553","article-title":"A case of postpartum thyroiditis following SARS-CoV-2 infection","volume":"68","author":"Mizuno","year":"2021","journal-title":"Endocr J"},{"key":"2025082711555066000_15.12.e252837.5","unstructured":"Farwell AP , Pearce EN . Sporadic painless, painful subacute and acute infectious thyroiditis. In: Braverman LE , ed. Werner & Ingbar\u2019s the thyroid: A fundamental and clinical text. 11th edition. Lippincott: Williams & Wilkins, 2021: 397\u20139."},{"key":"2025082711555066000_15.12.e252837.6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s40618-017-0778-8","article-title":"Thyroid dysfunctions secondary to cancer immunotherapy","volume":"41","author":"Chalan","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"2025082711555066000_15.12.e252837.7","first-page":"708333","article-title":"Coronavirus Disease 2019 and the Thyroid - Progress and Perspectives","volume":"2021","author":"Inaba","year":"2019","journal-title":"Front Endocrinol"},{"key":"2025082711555066000_15.12.e252837.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"2025082711555066000_15.12.e252837.9","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"2025082711555066000_15.12.e252837.10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s40618-020-01436-w","article-title":"Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis","volume":"44","author":"Rotondi","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"2025082711555066000_15.12.e252837.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"2025082711555066000_15.12.e252837.12","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa108","article-title":"Endocrine significance of SARS-CoV-2's reliance on ACE2","volume":"161","author":"Lazartigues","year":"2020","journal-title":"Endocrinology"},{"key":"2025082711555066000_15.12.e252837.13","doi-asserted-by":"crossref","DOI":"10.1530\/ETJ-22-0074","article-title":"Detection of SARS-CoV-2 infection in thyroid follicular cells from a COVID-19 autopsy series","volume":"11","author":"Macedo","year":"2022","journal-title":"Eur Thyroid J"},{"key":"2025082711555066000_15.12.e252837.14","doi-asserted-by":"crossref","DOI":"10.1530\/ETJ-22-0005","article-title":"Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis","volume":"11","author":"Jakovac","year":"2022","journal-title":"Eur Thyroid J"},{"key":"2025082711555066000_15.12.e252837.15","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1932467"},{"key":"2025082711555066000_15.12.e252837.16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0627"},{"key":"2025082711555066000_15.12.e252837.17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.617089","article-title":"Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases","volume":"11","author":"Vojdani","year":"2020","journal-title":"Front Immunol"},{"key":"2025082711555066000_15.12.e252837.18","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.935075","article-title":"A prospective observational study of 42 patients with COVID-19 infection and a history of hepatitis C virus infection and thyroid disease with follow-up thyroid function and autoantibody testing","volume":"27","author":"Cristinel Badiu","year":"2021","journal-title":"Med Sci Monit"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:55:58Z","timestamp":1756320958000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bcr-2022-252837"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252837","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}