{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:15:52Z","timestamp":1785701752653,"version":"3.56.0"},"reference-count":11,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Steroids are commonly prescribed medications that have a wide range of adverse effects. Bradycardia is one of the rare but significant side effects of steroid use, and only a few cases have been reported with bradycardia as a side effect. In this report, we present a case of a woman in her early 50s who developed severe symptomatic sinus bradycardia following high-dose administration of intravenous hydrocortisone, initiated for acute exacerbation of Crohn\u2019s disease. Her symptoms entirely resolved after discontinuation of the steroid. This case highlights the importance of obtaining baseline ECG and cardiac monitoring in patients treated with pulsed high-dose steroids.<\/jats:p>","DOI":"10.1136\/bcr-2022-252878","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T11:55:48Z","timestamp":1668426948000},"page":"e252878","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Hydrocortisone-induced symptomatic sinus bradycardia"],"prefix":"10.1136","volume":"15","author":[{"given":"Mohammed","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Cardiology, Betsi Cadwaladr University Health Board, Wrexham, Gwynedd, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-7270","authenticated-orcid":false,"given":"Success Tobore","family":"Oyibo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Betsi Cadwaladr University Health Board, Wrexham, Gwynedd, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Dalvi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Betsi Cadwaladr University Health Board, Wrexham, Gwynedd, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cowell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Betsi Cadwaladr University Health Board, Wrexham, Gwynedd, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"2025082623441781000_15.11.e252878.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"2025082623441781000_15.11.e252878.2","first-page":"e15065","article-title":"Steroid-Induced sinus bradycardia","volume":"44","author":"Khandelwal","year":"2021","journal-title":"Cureus"},{"key":"2025082623441781000_15.11.e252878.3","first-page":"443","article-title":"Steroid side effects side effects of corticosteroids side effects of corticosteroids corticosteroid medications","volume":"58","author":"Grennan","year":"1998","journal-title":"Am Fam Physician"},{"key":"2025082623441781000_15.11.e252878.4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1715163515597451","article-title":"Corticosteroid-Induced bradycardia: case report and review of the literature","volume":"148","author":"Stroeder","year":"2015","journal-title":"Can Pharm J"},{"key":"2025082623441781000_15.11.e252878.5","doi-asserted-by":"crossref","first-page":"e04678","DOI":"10.1002\/ccr3.4678","article-title":"An uncommon side effect of a very commonly used medication: a case report on hydrocortisone-induced bradycardia","volume":"9","author":"Payus","year":"2021","journal-title":"Clin Case Rep"},{"key":"2025082623441781000_15.11.e252878.6","first-page":"1","article-title":"Bradycardia associated with steroid use for laryngeal edema in an adult: a case report and literature review","volume":"2016","author":"John","year":"2016","journal-title":"Case Rep Cardiol"},{"key":"2025082623441781000_15.11.e252878.7","doi-asserted-by":"crossref","first-page":"117954761983102","DOI":"10.1177\/1179547619831026","article-title":"Acute symptomatic sinus bradycardia in high-dose methylprednisolone therapy in a woman with inflammatory myelitis: a case report and review of the literature","volume":"12","author":"Sodero","year":"2019","journal-title":"Clin Med Insights Case Rep"},{"key":"2025082623441781000_15.11.e252878.8","first-page":"e353","article-title":"Corticosteroid-Induced sinus bradycardia in a young boy with adrenal insufficiency and sepsis","volume":"119","author":"Cimbek","year":"2021","journal-title":"Arch Argent Pediatr"},{"key":"2025082623441781000_15.11.e252878.9","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-015-0701-x","article-title":"Acute symptomatic sinus bradycardia in a woman treated with pulse dose steroids for multiple sclerosis: a case report","volume":"9","author":"Kundu","year":"2015","journal-title":"J Med Case Rep"},{"key":"2025082623441781000_15.11.e252878.10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242058","article-title":"Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19","volume":"14","author":"Hallberg","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082623441781000_15.11.e252878.11","unstructured":"Adverse Drug Reaction Probability Scale (Naranjo) in Drug Induced Liver Injury [Internet]. 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