{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:01Z","timestamp":1756275001927,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,2,1]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Gitelman syndrome (GS) is an autosomal recessive tubulopathy caused by dysfunction of the thiazide-sensitive sodium\u2013chloride cotransporter, which leads to hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. Patients with GS show varied clinical features due to hypokalaemia: tetany, muscle weakness, periodical paralysis and constipation, which is one of the most frequent ones. This paper presents the case of a woman in her 40s referred to our endocrinology department for severe hypokalaemia. After biochemical and genetic analyses, a diagnosis of GS was established. Concurrently, the patient suffered from refractory constipation due to hypokalaemia and underwent a total colectomy with ileorectal anastomosis, which cured both disorders without any medication for 3\u2009years.<\/jats:p>","DOI":"10.1136\/bcr-2022-252916","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T12:12:43Z","timestamp":1675771963000},"page":"e252916","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Total colectomy for poorly controlled hypokalaemia due to Gitelman syndrome"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-4871","authenticated-orcid":false,"given":"Tetsuya","family":"Kawahara","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism, Shin Komonji Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Inazu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, Ritsumeikan University\u2014Biwako Kusatsu Campus, Kusatsu, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ishida","sequence":"additional","affiliation":[{"name":"Surgery, Shin Komonji Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2025082622535094000_16.2.e252916.1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/j.2040-4603.2018.tb00044.x","article-title":"Colonic potassium absorption and secretion in health and disease","volume":"8","author":"Rajendran","year":"2018","journal-title":"Compr 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