{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:17:30Z","timestamp":1790284650451,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,25]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>An invasive mole is an uncommon type of gestational trophoblastic disease, and if considering its implantation in an interstitial extrauterine location, we are facing a rarer condition.<\/jats:p>\n               <jats:p>There are 14 cases described of interstitial ectopic gestational trophoblastic disease. As far as we know, we present the third case of invasive mole within interstitial location, in this case with pulmonary metastases.<\/jats:p>\n               <jats:p>The diagnosis of an interstitial implantation is challenging. Our patient was initially diagnosed with an intrauterine hydatidiform molar pregnancy, and a uterine aspiration was performed. Two weeks later, she presented with haemodynamical instability due to a severe haemoperitoneum. A laparotomy was immediately performed and revealed a ruptured interstitial pregnancy with molar vesicle extrusion. Besides its rarity, we highlight the clinical presentation with hypovolaemic shock due to rupture of ectopic pregnancy in a young nulliparous woman, which required an emergent surgical approach with lifesaving purpose while preserving future fertility.<\/jats:p>","DOI":"10.1136\/bcr-2022-252925","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T10:31:26Z","timestamp":1670409086000},"page":"e252925","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Life-threatening rupture of interstitial ectopic pregnancy: a rare presentation of metastatic invasive mole"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-8585","authenticated-orcid":false,"given":"Joana","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Nazar\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Carralas","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Garcia de Orta EPE, Almada, Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"2025082713024408000_15.12.e252925.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.857"},{"key":"2025082713024408000_15.12.e252925.2","doi-asserted-by":"crossref","first-page":"100813","DOI":"10.1016\/j.gore.2021.100813","article-title":"Gestational trophoblastic neoplasia presenting as an interstitial ectopic pregnancy","volume":"37","author":"Toal","year":"2021","journal-title":"Gynecol Oncol Rep"},{"key":"2025082713024408000_15.12.e252925.3","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.mjafi.2015.11.009","article-title":"A cornual invasive hydatiform mole: a literature review","volume":"72","author":"Khlifi","year":"2016","journal-title":"Med J Armed Forces India"},{"key":"2025082713024408000_15.12.e252925.4","first-page":"891","article-title":"Molar cornual ectopic 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