{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:29:48Z","timestamp":1758893388595,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,12,15]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive syndrome, and consanguinity has been reported in 20%\u201340% of cases. It is characterised by palmoplantar hyperkeratosis associated with severe early-onset periodontitis and premature loss of primary and permanent teeth. This report describes a case of PLS in a female patient with consanguineously married parents. The patient reported mobile upper front teeth. Clinical examination revealed presence of marked palmoplantar hyperkeratosis.<\/jats:p>\n               <jats:p>Symmetric, well-demarcated, yellowish, keratotic and confluent plaques were seen on the skin of her palms and soles. Intraoral periodontal examination revealed erythematous gingiva with generalised periodontal pockets. Generalised mobility of teeth was present with clinically missing lower anterior teeth. Based on clinical and radiographic feature and the patient\u2019s medical, dental and family history, a diagnosis of PLS was made.<\/jats:p>","DOI":"10.1136\/bcr-2022-252992","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T10:30:22Z","timestamp":1672050622000},"page":"e252992","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Multidisciplinary management of Papillon-Lefevre syndrome as a result of consanguineous marriage"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-9433","authenticated-orcid":false,"given":"Narayane","family":"Ramkumar","sequence":"first","affiliation":[{"name":"Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanumanth","family":"Sankar","sequence":"additional","affiliation":[{"name":"Orthodontics and Dentofacial Orthopedics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"2025082711070626000_15.12.e252992.1","doi-asserted-by":"crossref","unstructured":"Abou Chedid JC , Salameh M , El-Outa A . 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