{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:07:03Z","timestamp":1756339623321,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft tissue sarcoma with a poor prognosis, affecting most commonly the extremities. The lungs constitute the most frequent location for distant metastases. Half of all MPNSTs arise in patients with neurofibromatosis type 1, while approximately 10% are radiation induced and the rest are sporadic.<\/jats:p>\n               <jats:p>The authors present a pregnant woman in her 40s with a sporadic MPNST of the lower limb and with lung metastases at diagnosis. Treatment consisted of interilioabdominal amputation, followed by adjuvant chemotherapy. Partial response and disease stabilisation were achieved with chemotherapy.<\/jats:p>\n               <jats:p>Surgical resection with negative margins is the only potentially curative therapy, while radiation therapy and chemotherapy might be useful in the neoadjuvant or adjuvant setting, but their advantage in survival is not demonstrated. In the reported case, chemotherapy permitted the achievement of partial response and stabilisation of the disease.<\/jats:p>","DOI":"10.1136\/bcr-2022-253070","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:40:23Z","timestamp":1712151623000},"page":"e253070","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Bulky malignant peripheral nerve sheath tumour of the left thigh in a pregnant woman presenting with a pathological fracture of the proximal femur"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-8947","authenticated-orcid":false,"given":"Diogo","family":"Catelas","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Centro Hospitalar Universitario de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-2556","authenticated-orcid":false,"given":"Duarte","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Centro Hospitalar Universitario de Santo Ant\u00f3nio, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Patr\u00edcia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Centro Hospitalar Universitario de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"2025082713112569000_17.4.e253070.1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.3467"},{"key":"2025082713112569000_17.4.e253070.2","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-020-02427-4","article-title":"Fungating malignant peripheral nerve sheath tumor arising from a slow-growing mass in the forearm: a case report and review of the literature","volume":"14","author":"Abdel Al","year":"2020","journal-title":"J Med Case 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