{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:35:41Z","timestamp":1792193741348,"version":"4.4.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,2,8]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Fibrillary glomerulonephritis (FGN) is a rare proliferative form of glomerular disease characterised by randomly oriented fibrillary deposits with a mean diameter of 20\u2009nm. It has a rare association with systemic lupus erythematosus (SLE). We report the case of a female in her mid-50's with a 20\u2009year history of SLE, who developed proteinuria due to FGN and had no histological evidence of lupus nephritis. She was maintained on azathioprine and prednisolone. A renal biopsy revealed randomly arranged fibrillary deposits that positively stained for DNAJB9, consistent with a diagnosis of FGN. Azathioprine was switched to mycophenolate mofetil, and the patient showed significant improvement in proteinuria. This case-based review describes the diagnosis, management and clinical outcome of FGN in association with SLE in the absence of lupus nephritis.<\/jats:p>","DOI":"10.1136\/bcr-2022-253388","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T09:39:18Z","timestamp":1676972358000},"page":"e253388","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Fibrillary glomerulonephritis in a patient with systemic lupus erythematosus with no evidence of lupus nephritis"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-3756","authenticated-orcid":false,"given":"Matthew Carl","family":"Whelband","sequence":"first","affiliation":[{"name":"Acute Medicine, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Willingham","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathiamalar","family":"Thirunavukkarasu","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Patrick","sequence":"additional","affiliation":[{"name":"Nephrology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"2025082700204286000_16.2.e253388.1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.ekir.2019.04.013","article-title":"Fibrillary glomerulonephritis: an update","volume":"4","author":"Rosenstock","year":"2019","journal-title":"Kidney Int Rep"},{"key":"2025082700204286000_16.2.e253388.2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ekir.2017.07.017","article-title":"DNAJB9 is a specific immunohistochemical marker for fibrillary glomerulonephritis","volume":"3","author":"Nasr","year":"2018","journal-title":"Kidney Int Rep"},{"key":"2025082700204286000_16.2.e253388.3","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.433"},{"key":"2025082700204286000_16.2.e253388.4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.kint.2019.03.021","article-title":"New developments in the diagnosis of fibrillary glomerulonephritis","volume":"96","author":"Nasr","year":"2019","journal-title":"Kidney Int"},{"key":"2025082700204286000_16.2.e253388.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00853.x"},{"key":"2025082700204286000_16.2.e253388.6","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08300910"},{"key":"2025082700204286000_16.2.e253388.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70138-5"},{"key":"2025082700204286000_16.2.e253388.8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000455390","article-title":"Clinical features and outcomes of a racially diverse population with fibrillary glomerulonephritis","volume":"45","author":"Payan Schober","year":"2017","journal-title":"Am J Nephrol"},{"key":"2025082700204286000_16.2.e253388.9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11255-011-0073-0","article-title":"Fibrillary glomerulonephritis in a patient with systemic lupus erythematosus: a rare association","volume":"45","author":"Bhat","year":"2013","journal-title":"Int Urol Nephrol"},{"key":"2025082700204286000_16.2.e253388.10","first-page":"15","article-title":"Fingerprint and other organised deposits in lupus nephritis","volume":"112","author":"Hvala","year":"2000","journal-title":"Wien Klin Wochenschr"},{"key":"2025082700204286000_16.2.e253388.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1168-z"},{"key":"2025082700204286000_16.2.e253388.12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03870319"},{"key":"2025082700204286000_16.2.e253388.13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu189"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-253388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:20:54Z","timestamp":1756279254000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-253388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,21]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/bcr-2022-253388"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-253388","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}