{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:26:31Z","timestamp":1764433591763,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,1,12]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Here, we describe a rare case of drug-induced unilateral ciliary body effusion precipitated by topical brinzolamide, presenting acutely with pain, angle closure and myopic shift.<\/jats:p>\n               <jats:p>Ciliary body effusion was suspected clinically and confirmed by ultrasound biomicroscopy. Brinzolamide was ceased, atropine instilled and the ciliary body effusion promptly resolved without need for further treatment. Brinzolamide is a sulfonamide-derived carbonic anhydrase inhibitor (CAI) commonly used in the treatment of glaucoma. Sulfite derivates can rarely cause ciliary and suprachoroidal effusions, so if ocular pain or visual changes develop, these need to be promptly assessed.<\/jats:p>","DOI":"10.1136\/bcr-2022-253390","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:10:31Z","timestamp":1737979831000},"page":"e253390","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Topical brinzolamide-induced ciliary body effusion with secondary angle closure and myopic shift"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-7056","authenticated-orcid":false,"given":"Chelsea","family":"Guymer","sequence":"first","affiliation":[{"name":"Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Galanopoulos","sequence":"additional","affiliation":[{"name":"Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"2025082703314166000_18.1.e253390.1","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1097\/IJG.0000000000000270","article-title":"Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis","volume":"25","author":"Murphy","year":"2016","journal-title":"J Glaucoma"},{"key":"2025082703314166000_18.1.e253390.2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5005\/jp-journals-10078-1261","article-title":"Drug-induced Acute Angle-closure Glaucoma: A Review","volume":"13","author":"Yang","year":"2019","journal-title":"J Curr Glaucoma Pract"},{"key":"2025082703314166000_18.1.e253390.3","first-page":"121","article-title":"Bilateral Choroidal Detachment Induced by Unilateral Application of a Fixed Combination of Topical Timolol Maleate and Brinzolamide","volume":"5","author":"Donmez","year":"2016","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"key":"2025082703314166000_18.1.e253390.4","doi-asserted-by":"crossref","first-page":"101152","DOI":"10.1016\/j.ajoc.2021.101152","article-title":"Multimodal etiology of drug induced angle closure with topical glaucoma therapy","volume":"23","author":"Mehta","year":"2021","journal-title":"Am J Ophthalmol Case Rep"},{"key":"2025082703314166000_18.1.e253390.5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/IJG.0000000000000742","article-title":"Drug-induced Myopia and Bilateral Angle Closure Secondary to Zolmitriptan","volume":"26","author":"Lee","year":"2017","journal-title":"J Glaucoma"},{"key":"2025082703314166000_18.1.e253390.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01365.x"},{"key":"2025082703314166000_18.1.e253390.7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ajo.2004.02.070","article-title":"Dorzolamide-induced choroidal detachment in a surgically untreated eye","volume":"138","author":"Goldberg","year":"2004","journal-title":"Am J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-253390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:31:48Z","timestamp":1756290708000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-253390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,27]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/bcr-2022-253390"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-253390","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}