{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:18:16Z","timestamp":1760347096835,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,4,7]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Destructive lesions in the craniofacial region especially in the jawbones, if associated with giant cells, include a spectrum of lesions that pose difficulty in diagnosis. The nature of such a lesion in the jawbones is questionable about whether it is a reactive\/benign lesion or aggressive\/non-aggressive. Clinical, radiological and histopathological correlation may be a reliable indicator to differentiate between the qualities of the lesion, which directly accounts for effective and individual planning of the treatment. Here we present a case of a woman in her late 20s with an unusual destructive lesion of the mandible.<\/jats:p>","DOI":"10.1136\/bcr-2022-253499","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T11:00:53Z","timestamp":1683198053000},"page":"e253499","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Aggressive giant cell lesion of mandible\u2013confusing to common: true neoplasm versus reactive lesion"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-3837","authenticated-orcid":false,"given":"Santha Devy","family":"Arumugam","sequence":"first","affiliation":[{"name":"Oral & Maxillofacial Pathology and Oral Microbiology, Sri Balaji Vidyapeeth University, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharathraj","family":"Kanniyappan","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Surgery, Sri Balaji Vidyapeeth University, Pondicherry, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-3654","authenticated-orcid":false,"given":"Umamaheswari","family":"Giri","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Pathology and Oral Microbiology, Sri Balaji Vidyapeeth University, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivaramakrishnan","family":"Muthanandam","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Pathology and Oral Microbiology, Sri Balaji Vidyapeeth University, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2025082700543641000_16.5.e253499.1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/0019-5154.139887","article-title":"Giant cells in dermatology","volume":"59","author":"Gupta","year":"2014","journal-title":"Indian J Dermatol"},{"key":"2025082700543641000_16.5.e253499.2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32831ac52e"},{"key":"2025082700543641000_16.5.e253499.3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4103\/jiaomr.jiaomr_81_18","article-title":"Classifying giant cell lesions: a review","volume":"30","author":"Ranjan","year":"2018","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"2025082700543641000_16.5.e253499.4","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ajpath.2019.02.006","article-title":"An overview of the derivation and function of multinucleated giant cells and their role in pathologic processes","volume":"189","author":"Brooks","year":"2019","journal-title":"Am J Pathol"},{"key":"2025082700543641000_16.5.e253499.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64882-1"},{"key":"2025082700543641000_16.5.e253499.6","first-page":"193","article-title":"Frequency of giant cell lesions in oral biopsies","volume":"6","author":"Mohajerani","year":"2009","journal-title":"J Dent Tehran Univ Med Sci"},{"key":"2025082700543641000_16.5.e253499.7","first-page":"125","article-title":"Central giant cell granuloma \u2013 an update","volume":"126","author":"Ramesh","year":"2020","journal-title":"J Oral Maxillo Fac Pathol"},{"key":"2025082700543641000_16.5.e253499.8","doi-asserted-by":"publisher","DOI":"10.1002\/path.5365"},{"key":"2025082700543641000_16.5.e253499.9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00126.x"},{"key":"2025082700543641000_16.5.e253499.10","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(53)90151-0"},{"key":"2025082700543641000_16.5.e253499.11","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90215-4"},{"key":"2025082700543641000_16.5.e253499.12","unstructured":"Lucas RB . Pathology of tumours of the oral tissues . 2nd ed. Baltimore: Williams & Wilkins, 1972: 239\u201346."},{"key":"2025082700543641000_16.5.e253499.13","unstructured":"KC D , Kumar SP , Jose M , et al . Aggressive central giant cell granuloma of the jaw-A case report. Journal of Oral Health Research 2012;3."},{"key":"2025082700543641000_16.5.e253499.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-006-0215-7"},{"key":"2025082700543641000_16.5.e253499.15","unstructured":"Rosenberg AE , Bone tumors . Dorfman and BogdanCzerniak. St. Louis: Mosby, 1998."},{"key":"2025082700543641000_16.5.e253499.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.02.060"},{"key":"2025082700543641000_16.5.e253499.17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/0973-029X.141350","article-title":"Computer assisted histomorphologic comparision and the expression of AgNORs in the central and peripheral giant cell lesions of the oral cavity and giant cell tumor of the long bone","volume":"18","author":"Kashyap","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"2025082700543641000_16.5.e253499.18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/ams.ams_232_18","article-title":"Management of central giant cell granulomas of the jaws: an unusual case report with critical appraisal of existing literature","volume":"9","author":"Jeyaraj","year":"2019","journal-title":"Ann Maxillofac Surg"},{"key":"2025082700543641000_16.5.e253499.19","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/85668294"},{"key":"2025082700543641000_16.5.e253499.20","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90094-K"},{"key":"2025082700543641000_16.5.e253499.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00477.x"},{"key":"2025082700543641000_16.5.e253499.22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/0973-029X.151310","article-title":"Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: an immunohistochemical analysis","volume":"18","author":"Vk","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"2025082700543641000_16.5.e253499.23","unstructured":"Rosenberg AE . Bone tumors. In: Howard D , ed. DorfmanandBogdanCzerniak. St. Louis: Mosby, 1998."},{"key":"2025082700543641000_16.5.e253499.24","unstructured":"Gnepp DR . Diagnostic Surgical Pathology of the Head and Neck . 2 ed. Philadelphia, PA, USA: Saunders Elsevier Inc, 2009."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-253499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:54:45Z","timestamp":1756281285000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-253499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,4]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/bcr-2022-253499"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-253499","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}