{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:23Z","timestamp":1756425743986,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"12","funder":[{"name":"NIH\/NCI Cancer Center Support Grant to MSKCC","award":["P30-CA008748"],"award-info":[{"award-number":["P30-CA008748"]}]},{"name":"Leukemia & Lymphoma Society to CG","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]},{"name":"Cycle for Survival Equinox to CG","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]},{"name":"The New York Eye and Ear Foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,26]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>A woman in her 70s experienced painless vision loss in the right eye for 1 month. Acute retinal necrosis-induced panuveitis was the referral diagnosis. With dense vitreous haze, a vitrectomy was performed for vitreous biopsy followed by multimodal imaging. Vitreous biopsy yielded negative PCR results for herpes viruses and only inflammatory cells. Post-vitrectomy imaging showed involuted but pervasive pigmentary foci in the outer retina and the retinal pigment epithelium. Concurrently, peripheral blood showed pancytosis with giant platelets and a Janus kinase 2 (<jats:italic>JAK2<\/jats:italic>) mutation, which prompted a haematological evaluation. CT and MRI revealed a right frontal lobe intra-axial mass, diagnosed as diffuse large B cell lymphoma (DLBCL). Subsequently, bone marrow aspirate confirmed the pathogenic V617F <jats:italic>JAK2<\/jats:italic> mutation. Following chemotherapy, the patient achieved lymphoma regression and uveitic quiescence. This is the first case report of acute unilateral panuveitis in a patient with <jats:italic>JAK2<\/jats:italic> mutation and DLBCL but without evidence of intraocular involvement.<\/jats:p>","DOI":"10.1136\/bcr-2022-253572","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T10:21:01Z","timestamp":1670235661000},"page":"e253572","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral panuveitis secondary to <i>JAK2<\/i> mutation-associated lymphoproliferative disease"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-2801","authenticated-orcid":false,"given":"Yafeng","family":"Li","sequence":"first","affiliation":[{"name":"Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, 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