{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:14:36Z","timestamp":1791566076590,"version":"4.3.4"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,22]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>We describe the first case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma. Our patient presented with progressive unsteadiness and numbness involving bilateral upper and lower limbs. He had symmetrical length-dependent lower motor neuron pattern of weakness and numbness involving both small and large fibres with prominent sensory ataxia. An extended workup for the polyneuropathy involving a serum paraneoplastic antineuronal antibody panel showed a positive reaction for anti-CV2 antibody. CT scan of the thorax, abdomen and pelvis revealed a right upper lung nodule and histopathological examination of the nodule revealed lung adenocarcinoma. He was scheduled for chemotherapy following his discharge and there was improvement of his sensorimotor polyneuropathy following his chemotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2022-253686","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T09:45:34Z","timestamp":1675417534000},"page":"e253686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Rare case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma"],"prefix":"10.1136","volume":"16","author":[{"given":"Marco","family":"Lizwan","sequence":"first","affiliation":[{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn Zhi Zheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute - Singapore General Hospital Campus, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-0294","authenticated-orcid":false,"given":"Sumit Kumar","family":"Sonu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute - Singapore General Hospital Campus, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"2025082711072009000_16.2.e253686.1","doi-asserted-by":"crossref","unstructured":"Martyn CN , Hughes RA . Epidemiology of peripheral neuropathy. J Neurol Neurosurg Psychiatry 1997.","DOI":"10.1136\/jnnp.62.4.310"},{"key":"2025082711072009000_16.2.e253686.2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.197"},{"key":"2025082711072009000_16.2.e253686.3","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/B978-0-7020-4088-7.00078-X","article-title":"Paraneoplastic disorders of the central and peripheral nervous systems","volume":"121","author":"Didelot","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"2025082711072009000_16.2.e253686.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04708-8"},{"key":"2025082711072009000_16.2.e253686.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.652"},{"key":"2025082711072009000_16.2.e253686.6","doi-asserted-by":"crossref","first-page":"e1873","DOI":"10.1212\/WNL.0000000000008472","article-title":"Amphiphysin-igg autoimmune neuropathy: a recognizable clinicopathologic syndrome","volume":"93","author":"Dubey","year":"2019","journal-title":"Neurology"},{"key":"2025082711072009000_16.2.e253686.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322175"},{"key":"2025082711072009000_16.2.e253686.8","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1212\/WNL.0000000000004803","article-title":"Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases","volume":"90","author":"Dubey","year":"2018","journal-title":"Neurology"},{"key":"2025082711072009000_16.2.e253686.9","doi-asserted-by":"crossref","first-page":"e954","DOI":"10.1212\/WNL.0000000000008061","article-title":"Autoimmune gait disturbance accompanying adaptor protein-3B2-igg","volume":"93","author":"Honorat","year":"2019","journal-title":"Neurology"},{"key":"2025082711072009000_16.2.e253686.10","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-2-22","article-title":"Paraneoplastic neurological syndromes","volume":"2","author":"Honnorat","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"2025082711072009000_16.2.e253686.11","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242082","article-title":"Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung","volume":"14","author":"Yap","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082711072009000_16.2.e253686.12","doi-asserted-by":"crossref","unstructured":"Yan J , Chen Z , Liang Y , et al . Anti-CV2\/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review. J Int Med Res 2020;48. doi:10.1177\/0300060520974466","DOI":"10.1177\/0300060520974466"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-253686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:07:30Z","timestamp":1756318050000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-253686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,3]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/bcr-2022-253686"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-253686","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}