{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:33:41Z","timestamp":1782232421717,"version":"3.54.5"},"reference-count":22,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,3,9]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Systemic sclerosis is a complex multisystem connective tissue disease resulting in fibrosis of the skin and internal organs. Exposure to corticosteroids can trigger scleroderma renal crisis, a life-threatening complication of the disease. Autoimmune disease following infection with COVID-19 is being increasingly recognised. The mechanisms of post-COVID-19 autoimmunity are likely multifactorial, involving immune dysregulation, molecular mimicry and the development of cross-reactive antibodies. There are currently only two reported cases of systemic sclerosis occurring post-COVID-19 infection.<\/jats:p>\n               <jats:p>We present the case of a female patient who developed systemic sclerosis post-COVID-19 infection. Following exposure to corticosteroids, the patient developed scleroderma renal crisis complicated by thrombotic microangiopathy, seizures and acute renal failure. Despite an antibody profile not typically associated with renal crisis (anti-topoisomerase positive, anti-RNA-polymerase III negative), the patient developed recurrent renal crisis with repeated exposure to corticosteroid therapy, highlighting the risk of steroid use in all patients with systemic sclerosis.<\/jats:p>","DOI":"10.1136\/bcr-2022-253735","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T03:46:31Z","timestamp":1679197591000},"page":"e253735","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Systemic sclerosis following COVID-19 infection with recurrent corticosteroid-induced scleroderma renal crisis"],"prefix":"10.1136","volume":"16","author":[{"given":"Mitchell","family":"Carroll","sequence":"first","affiliation":[{"name":"General Medicine, Renal, Ballarat Health Services, Ballarat, Victoria, 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