{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:05Z","timestamp":1756285805130,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,6,21]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>In this report, we present a case of a patient with a 30-year history of orbital asymmetry who presented with metastatic human epidermal growth factor receptor 2 (<jats:italic>HER2<\/jats:italic>) positive lacrimal\/salivary gland ductal adenocarcinoma. The patient was treated with chemoradiotherapy and trastuzumab. Tumours of lacrimal gland origin are rare, and unfortunately can frequently present in late stage. There are no current guidelines on the optimal treatment of metastatic lacrimal gland tumours, in particular those with <jats:italic>HER2<\/jats:italic> amplified malignancy. This case highlights a unique presentation of a rare disease, and the potential for targeted therapy.<\/jats:p>","DOI":"10.1136\/bcr-2022-253928","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T14:00:19Z","timestamp":1688133619000},"page":"e253928","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic <i>HER2<\/i> lacrimal\/salivary gland duct adenocarcinoma"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5215-7793","authenticated-orcid":false,"given":"Ruaa Abdullah","family":"Mansi","sequence":"first","affiliation":[{"name":"Internal Medicine, Royal College of Physicians of Ireland, and Taibah University, Dublin, and Madina, Ireland, and Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Br\u00edd","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Fulcher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Endocrine, Connolly Hospital Blanchardstown, and Royal College of Surgeon in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"2025082701404982000_16.6.e253928.1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.5999\/aps.2012.39.5.578","article-title":"Primary adenocarcinoma of the Lacrimal gland","volume":"39","author":"Baek","year":"2012","journal-title":"Arch Plast Surg"},{"key":"2025082701404982000_16.6.e253928.2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1053\/joms.2002.30595","article-title":"Adenocarcinoma of the Lacrimal gland: report of a case","volume":"60","author":"Clauser","year":"2002","journal-title":"J Oral Maxillofac Surg"},{"key":"2025082701404982000_16.6.e253928.3","article-title":"Her-2 amplified Lacrimal gland carcinoma with response to Lapatinib treatment","volume":"2015","author":"Dennie","year":"2015","journal-title":"Case Rep Oncol Med"},{"key":"2025082701404982000_16.6.e253928.4","unstructured":"Mueller AJ , Czyz CN . 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