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Further, CT of the chest showed mediastinal lymphadenopathy with eggshell calcification and interstitial fibrosis consistent with silicosis and fibrotic non-specific interstitial pneumonitis. The patient was started on pulse monthly cyclophosphamide for six cycles, and steroids were given for 4 weeks and tapered. Tadalafil and amlodipine were given for his pulmonary artery hypertension and Raynaud\u2019s phenomenon, respectively. This case also highlights the importance of periodic screening of the workers exposed to silica dust to prevent silicosis.<\/jats:p>","DOI":"10.1136\/bcr-2022-253952","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:30:28Z","timestamp":1674016228000},"page":"e253952","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Silica associated systemic sclerosis: an occupational health hazard"],"prefix":"10.1136","volume":"16","author":[{"given":"Dhyana S","family":"Shivakumar","sequence":"first","affiliation":[{"name":"General Medicine, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-0739","authenticated-orcid":false,"given":"Navaneeth Sadananda","family":"Kamath","sequence":"additional","affiliation":[{"name":"General Medicine, Kasturba Medical College, Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Naik","sequence":"additional","affiliation":[{"name":"General Medicine, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"2025082723582288000_16.1.e253952.1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/BOR.0000000000000785","article-title":"Scleroderma epidemiology update","volume":"33","author":"Calderon","year":"2021","journal-title":"Curr Opin Rheumatol"},{"key":"2025082723582288000_16.1.e253952.2","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/1756-185X.13716","article-title":"Prevalence and incidence of systemic sclerosis: a systematic review and meta-analysis","volume":"22","author":"Zhong","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"2025082723582288000_16.1.e253952.3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.7326\/0003-4819-110-6-446","article-title":"Interleukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration","volume":"110","author":"Kahaleh","year":"1989","journal-title":"Ann Intern Med"},{"key":"2025082723582288000_16.1.e253952.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60235-9"},{"key":"2025082723582288000_16.1.e253952.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.534"},{"key":"2025082723582288000_16.1.e253952.6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaad.2014.11.027","article-title":"Association of occupational exposure with features of systemic sclerosis","volume":"72","author":"Marie","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"2025082723582288000_16.1.e253952.7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000247513","article-title":"Silica and trichloroethylene-induced progressive systemic sclerosis","volume":"184","author":"Y\u00e1\u00f1ez D\u00edaz","year":"1992","journal-title":"Dermatology"},{"key":"2025082723582288000_16.1.e253952.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb04189.x"},{"key":"2025082723582288000_16.1.e253952.9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5114\/reum.2019.83241","article-title":"Scleroderma-like syndrome in a woman with silicone breast implants - case report and critical review of the literature","volume":"57","author":"Wro\u0144ski","year":"2019","journal-title":"Reumatologia"},{"key":"2025082723582288000_16.1.e253952.10","doi-asserted-by":"crossref","first-page":"984907","DOI":"10.3389\/fmed.2022.984907","article-title":"Exposure to silica and systemic sclerosis: a retrospective cohort study based on the Canadian scleroderma Research Group","volume":"9","author":"Muntyanu","year":"2022","journal-title":"Front Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-253952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:58:33Z","timestamp":1756364313000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-253952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,17]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1136\/bcr-2022-253952"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-253952","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}