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We report a rare occurrence of PB-induced SH secondary to intrathecal administration of PB in a child with <jats:italic>A. baumanii<\/jats:italic> XDR ventriculitis. We describe the management of him and a brief review of PB.<\/jats:p>","DOI":"10.1136\/bcr-2022-253959","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T11:20:24Z","timestamp":1681212024000},"page":"e253959","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Rare occurrence of polymyxin B-induced hyperpigmentation in a child with ventriculitis"],"prefix":"10.1136","volume":"16","author":[{"given":"Diana Noma","family":"Fitzrol","sequence":"first","affiliation":[{"name":"Department of Neurosciences, School of Medical Sciences, Hospital Universiti Sains Malaysia, Kota Bahru, Kelantan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song Yee","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medical Sciences, Hospital Universiti Sains Malaysia, Kota Bahru, Kelantan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asyraf","family":"Suhaimi","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy & Drug Information Unit, Hospital Universiti Sains Malaysia, Kota Bahru, Kelantan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-597X","authenticated-orcid":false,"given":"Tat Boon","family":"Yeap","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"2025082710083509000_16.4.e253959.1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2019.04.180212"},{"key":"2025082710083509000_16.4.e253959.2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40360-018-0226-1","article-title":"Polymyxin b-induced skin hyperpigmentation: a rare case report and literature review","volume":"19","author":"Zheng","year":"2018","journal-title":"BMC Pharmacol Toxicol"},{"key":"2025082710083509000_16.4.e253959.3","doi-asserted-by":"crossref","DOI":"10.3390\/membranes10080181","article-title":"Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance","volume":"10","author":"Ayoub Moubareck","year":"2020","journal-title":"Membranes (Basel)"},{"key":"2025082710083509000_16.4.e253959.4","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20160058"},{"key":"2025082710083509000_16.4.e253959.5","doi-asserted-by":"crossref","unstructured":"Li J , Nation RL , Kaye KS . 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