{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:35:07Z","timestamp":1758818107799,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,10]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>We present a rare case of an extragonadal retroperitoneal yolk sac tumour in an adult male, who presented with severe abdominal pain to his local hospital. Imaging revealed a large retroperitoneal soft tissue mass with no evidence of metastases. Initial biopsy demonstrated poorly differentiated carcinoma, favoured to be renal cell carcinoma. The patient underwent surgical resection following re-presentation with severe abdominal pain and significant interval enlargement of the mass. Laparotomy revealed a renal tumour that had ruptured through the left mesocolon into the peritoneal cavity. Postoperative histopathological examination revealed a yolk sac tumour involving the kidney, perinephric fat, renal sinus fat, renal hilar lymph node and colonic mesentery. Immunohistochemical staining for alpha-fetoprotein and glypican 3 was positive in the tumour cells without evidence of other germ cell elements, confirming the diagnosis of a pure yolk sac tumour. To our knowledge, this is an extremely rare case of a primary pure yolk sac tumour arising from the kidney in an adult.<\/jats:p>","DOI":"10.1136\/bcr-2022-254024","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:01:10Z","timestamp":1685095270000},"page":"e254024","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Pure primary renal yolk sac tumour in an adult: extremely rare clinical finding"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-8529","authenticated-orcid":false,"given":"Ellen","family":"Maclean","sequence":"first","affiliation":[{"name":"Department of Urology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Barns","sequence":"additional","affiliation":[{"name":"Department of Urology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Urology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"2025082701232804000_16.5.e254024.1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.ijporl.2014.06.016","article-title":"Extragonadal primary yolk SAC tumour of temporal bone","volume":"78","author":"Narula","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025082701232804000_16.5.e254024.2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2195"},{"key":"2025082701232804000_16.5.e254024.3","doi-asserted-by":"crossref","unstructured":"Rubio-Fern\u00e1ndez A , Retamero JA , Nogales FF . 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