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After repeat admissions and prolonged inpatient stay from compounded septicaemia, a diagnosis of programmed cell death 1 (PD-1) inhibitor-induced hypophysitis was confirmed, with remarkable improvement on commencement of cortisol replacement.<\/jats:p>\n               <jats:p>While this side effect is known to oncologists, the non-specific symptoms and a lack of familiarity with PD-1 inhibitor and programmed cell death ligand 1 inhibitor therapies in other medical fields can result in diagnostic delays if not actively searching for hypophysitis.<\/jats:p>\n               <jats:p>Intractable nausea, vomiting and weight loss, even in the absence of hyponatraemia or hypoglycaemia, should trigger physicians to consider hypophysitis.<\/jats:p>","DOI":"10.1136\/bcr-2022-254034","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:13Z","timestamp":1740441313000},"page":"e254034","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["PD-1 inhibitor-induced thyroiditis and ACTH deficiency"],"prefix":"10.1136","volume":"18","author":[{"given":"Nayab","family":"Shah","sequence":"first","affiliation":[{"name":"St John of God Midland Public and Private Hospitals, Midland, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Prentice","sequence":"additional","affiliation":[{"name":"Internal medicine, Royal Perth Hospital, Perth, Australian Capital Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrin","family":"Jayasundera","sequence":"additional","affiliation":[{"name":"St John of God Midland Public and 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hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation","volume":"66","author":"Sekizaki","year":"2019","journal-title":"Endocr J"}],"container-title":["BMJ Case 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