{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:16Z","timestamp":1756339396278,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,7,23]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. We present a case of a patient with a history of two hospitalisations for unexplained recurrence of immediate-type hypersensitivity reactions and anaphylaxis who was diagnosed with PEG allergy in early childhood. Subsequently, he was instructed to avoid using PEG-containing daily necessities and drugs. However, in middle childhood, he presented with immediate-type hypersensitivity reactions after taking PEG-free antibiotics. The prick test was positive for the whole drug but negative for its active ingredient. PEG can cross-react with compounds with a C\u2013C\u2013O skeleton as analogue substances; accordingly, the presence of a substance with a similar skeleton in the additive may have been the causative factor. Our findings indicate that patients with PEG allergy may experience immediate-type hypersensitivity reactions to analogue substances.<\/jats:p>","DOI":"10.1136\/bcr-2022-254040","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:55:39Z","timestamp":1693313739000},"page":"e254040","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Patients with polyethylene glycol allergy can experience immediate-type hypersensitivity reactions after exposure to analog substances"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-2120","authenticated-orcid":false,"given":"Yosuke","family":"Yoshimoto","sequence":"first","affiliation":[{"name":"Allergy and Pulmonology, Fukuoka Children's Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-9016","authenticated-orcid":false,"given":"Junichiro","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Allergy and Pulmonology, Fukuoka Children's Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"2025082701265479000_16.8.e254040.1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12760"},{"key":"2025082701265479000_16.8.e254040.2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaip.2020.09.029","article-title":"Polyethylene glycol-induced systemic allergic reactions (Anaphylaxis)","volume":"9","author":"Sellaturay","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082701265479000_16.8.e254040.3","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jaip.2018.12.003","article-title":"Immediate hypersensitivity to polyethylene glycols and polysorbates: more common than we have recognized","volume":"7","author":"Stone","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082701265479000_16.8.e254040.4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.alit.2022.05.007","article-title":"Serum polyethylene glycol-specific IGE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines","volume":"71","author":"Mouri","year":"2022","journal-title":"Allergol Int"},{"key":"2025082701265479000_16.8.e254040.5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.18176\/jiaci.0447","article-title":"Recurrent immediate type hypersensitivity reaction induced by Macrogol in a 3-year-old boy","volume":"30","author":"Hamano","year":"2020","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2025082701265479000_16.8.e254040.6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.20471\/acc.2018.57.01.26","article-title":"Urticaria as a rare side effect of polyethylene glycol-3350 in a child: case report","volume":"57","author":"Sari G\u00f6kay","year":"2018","journal-title":"Acta Clin Croat"},{"key":"2025082701265479000_16.8.e254040.7","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1021\/acsbiomaterials.7b00147","article-title":"Cross-reactivity of select PEG-binding antibodies to other polymers containing a C-C-O backbone","volume":"3","author":"McCallen","year":"2017","journal-title":"ACS Biomater Sci Eng"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-254040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:27:04Z","timestamp":1756283224000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-254040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":7,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,29]]},"published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1136\/bcr-2022-254040"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-254040","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,8]]}}}