{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:58Z","timestamp":1756425778303,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,9,9]]},"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>A man in his 40s, with no tobacco or alcohol habit, was referred to the otorhinolaryngology department presenting with a 2-month history of enlarged left cervical lymphadenopathy with no other signs or symptoms. The ear, nose and throat examination showed no abnormalities apart from the described lymphadenopathy. An ultrasound scan suggested these nodes to be part of either an inflammatory or a malignant process. Subsequent positron emission tomography-CT proved those lymph nodes to be metabolically active, as well as others within the thorax. Cervicotomy was performed and the histopathological analysis showed dilated sinuses and histiocytes with emperipolesis. Suspecting Rosai-Dorfman disease (RDD), high-dose steroid therapy was started; but given no improvement was observed, a second cervicotomy was performed, with the histopathological diagnosis of the latter of Hodgkin\u2019s lymphoma. The present article aims to emphasise the need to exclude haematological disorders whenever RDD histology is observed, given their possible coexistence, and a worse outcome and clinical and histopathological semblance.<\/jats:p>","DOI":"10.1136\/bcr-2022-254152","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T22:50:15Z","timestamp":1695077415000},"page":"e254152","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of Rosai-Dorfman disease and Hodgkin\u2019s lymphoma in a patient with cervical lymphadenopathy"],"prefix":"10.1136","volume":"16","author":[{"given":"Elena","family":"Gonz\u00e1lez Turienzo","sequence":"first","affiliation":[{"name":"Otorrinolaringolog\u00eda, Hospital Universitario Doctor Peset, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Dom\u00ednguez Celis","sequence":"additional","affiliation":[{"name":"Otorrinolaringolog\u00eda, Hospital Universitario Doctor Peset, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Mart\u00ednez Ruiz de Apodaca","sequence":"additional","affiliation":[{"name":"Otorrinolaringolog\u00eda, Hospital Universitario Doctor Peset, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-1550","authenticated-orcid":false,"given":"Francisco","family":"Pons Rocher","sequence":"additional","affiliation":[{"name":"Otorrinolaringolog\u00eda, Hospital Universitario Doctor Peset, Valencia, Spain"},{"name":"Cirurgia (Otorhinolaryngology), Universitat de Valencia Facultat de Medicina i Odontologia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"2025082800385696000_16.9.e254152.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-839753"},{"key":"2025082800385696000_16.9.e254152.2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.humpath.2021.12.013","article-title":"Cyclin D1 expression in Rosai-Dorfman disease: a near-constant finding that is not invariably associated with mitogen-activated protein kinase\/extracellular signal-regulated kinase pathway activation","volume":"121","author":"Garces","year":"2022","journal-title":"Hum Pathol"},{"key":"2025082800385696000_16.9.e254152.3","first-page":"ZM01","article-title":"Emperipolesis \u2013 A review","volume":"8","author":"Rastogi","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"2025082800385696000_16.9.e254152.4","first-page":"7930823","article-title":"Simultaneous occurrence of Rosai\u2013Dorfman disease and nodal marginal zone lymphoma in a patient with Sj\u00f6gren\u2019s syndrome","volume":"2018","author":"Gorodetskiy","year":"2018","journal-title":"Case Rep Hematol"},{"key":"2025082800385696000_16.9.e254152.5","doi-asserted-by":"crossref","first-page":"2050313X211046455","DOI":"10.1177\/2050313X211046455","article-title":"Emergence of cutaneous Rosai\u2013Dorfman disease during immunosuppressive treatment of follicular B-cell lymphoma: A case report","volume":"9","author":"Kipfer","year":"2021","journal-title":"SAGE Open Med Case Rep"},{"key":"2025082800385696000_16.9.e254152.6","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206733"},{"key":"2025082800385696000_16.9.e254152.7","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219626"},{"key":"2025082800385696000_16.9.e254152.8","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215271","article-title":"Rosai\u2013Dorfman disease between proliferation and Neoplasia","volume":"14","author":"Elbaz Younes","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2025082800385696000_16.9.e254152.9","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1111\/bjd.16036","article-title":"Image gallery: Metachronic occurrence of primary cutaneous marginal zone B-cell lymphoma and primary cutaneous Rosai-Dorfman disease in the same patient","volume":"177","author":"Gonz\u00e1lez-Quesada","year":"2017","journal-title":"Br J Dermatol"},{"key":"2025082800385696000_16.9.e254152.10","doi-asserted-by":"crossref","unstructured":"Roccuzzo G , Avallone G , Cavallo F , et al . Synchronous occurrence of primary cutaneous B\u2010Cell lymphoma and cutaneous Rosai\u2013Dorfman disease in distinct lesions: A unique Association. J Cutan Pathol January 13, 2023. doi:10.1111\/cup.14391","DOI":"10.1111\/cup.14391"},{"key":"2025082800385696000_16.9.e254152.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0156-x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-254152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:39:05Z","timestamp":1756366745000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-254152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,18]]},"published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1136\/bcr-2022-254152"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-254152","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}