{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T22:01:31Z","timestamp":1778191291717,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,10]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Primary signet-ring cell carcinoma of the uterus is rare and requires exclusion of possible metastatic tumour to the uterus. We report a case of a woman in her 70s who underwent hysteroscopy and a polypectomy for a polyp arising from the uterine wall. On histological examination, malignant cells with signet-ring cell morphology were found within the fragments of endometrial tissue. Immunohistochemical studies indicated a metastatic adenocarcinoma possibly from the gastrointestinal tract. Additional radiological investigations revealed a possible primary gastric tumour, which was further confirmed on subsequent biopsies. This case illustrates that gastric carcinomas can rarely metastasise to the endometrium and highlights the importance of clinical correlation in arriving at the final diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2022-254190","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T11:02:17Z","timestamp":1684839737000},"page":"e254190","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic signet-ring carcinoma to the uterus presenting as an endometrial polyp"],"prefix":"10.1136","volume":"16","author":[{"given":"Ramzi","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Histopathology, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly Yanlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Histopathology, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill Cheng Sim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynaecology, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihir Gudi","family":"Ananta","sequence":"additional","affiliation":[{"name":"Pathology, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"2025082700502975000_16.5.e254190.1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026844","article-title":"Primary signet ring cell carcinoma of the uterine cervix: a case report","volume":"100","author":"Kim","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"2025082700502975000_16.5.e254190.2","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7819-10-7","article-title":"A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: immunohistochemical and molecular studies and review of the literature","volume":"10","author":"Giordano","year":"2012","journal-title":"World J Surg Oncol"},{"key":"2025082700502975000_16.5.e254190.3","unstructured":"WHO Classification of Tumours Editorial Board . Female genital tumours, WHO classification of tumours series, 5th Ed.; Vol. 4. Lyon (France) International Agency for Research on Cancer; 2020. Available: https:\/\/publications.iarc.fr\/592"},{"key":"2025082700502975000_16.5.e254190.4","article-title":"Primary endometrial adenocarcinoma with signet-ring cells: a rarely observed case and review of the literature","volume":"2015","author":"Akkalp","year":"2015","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082700502975000_16.5.e254190.5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001348"},{"key":"2025082700502975000_16.5.e254190.6","first-page":"82","article-title":"Signet ring cell of the non-neoplastic endometrium: a case report and literature review","volume":"1","author":"Lim","year":"2012","journal-title":"J Clin Gynecol Obstet"},{"key":"2025082700502975000_16.5.e254190.7","doi-asserted-by":"publisher","DOI":"10.1309\/RL5H-VC5D-9WE2-X71H"},{"key":"2025082700502975000_16.5.e254190.8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<1978::AID-CNCR2820530929>3.0.CO;2-1"},{"key":"2025082700502975000_16.5.e254190.9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/PGP.0000000000000516","article-title":"Secondary tumors of the gynecologic tract: a clinicopathologic analysis","volume":"38","author":"Karpathiou","year":"2019","journal-title":"Int J Gynecol Pathol"},{"key":"2025082700502975000_16.5.e254190.10","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.3892\/ol.2017.6822","article-title":"Metastasis of breast cancer to an endometrial Polyp, the Cervix and a Leiomyoma: a case report and review of the literature","volume":"14","author":"Razia","year":"2017","journal-title":"Oncol Lett"},{"key":"2025082700502975000_16.5.e254190.11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3892\/mco.2016.1035","article-title":"Metastatic gastric cancer to the female genital tract","volume":"5","author":"Matsushita","year":"2016","journal-title":"Mol Clin Oncol"},{"key":"2025082700502975000_16.5.e254190.12","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ygyno.2005.01.055","article-title":"Gastric adenocarcinoma presenting as uterine metastasis - a case report","volume":"97","author":"Tsoi","year":"2005","journal-title":"Gynecol Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-254190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:50:38Z","timestamp":1756281038000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-254190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,23]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/bcr-2022-254190"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-254190","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}