{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:16:16Z","timestamp":1770884176661,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,7,28]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>A woman in her 50s presented to her general practitioner (GP) with an 8-month history of multiple painful subcutaneous nodules of various sizes in her trunk and limbs. Her previous GP made the clinical diagnosis of lipoma when they presented as non-painful nodules 2 years ago. Initial ultrasound demonstrated multiple lipomata with the largest size in the left upper thighs displaying features of subtle internal vascularity, entirely contained within the subcutaneous layer. MRI scan of thigh lesions showed multiple angiolipomas consistent with the entity of Dercum\u2019s disease. Subsequent biopsy histology confirmed the image diagnosis of angiolipoma. She was referred to a musculoskeletal oncological surgeon for evaluation and reassurance regarding optimising medical management of her associated obesity. Her angiolipoma and obesity are well managed by her GP. This case highlights the diagnostic workup of a rare variant of lipoma, Dercum\u2019s disease. The differential diagnosis of multiple painful lipomas was reviewed and discussed, consequently leading to the discussion of managing the associated obesity in this case.<\/jats:p>","DOI":"10.1136\/bcr-2022-254263","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T13:17:56Z","timestamp":1691673476000},"page":"e254263","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Presentation of multiple painful subcutaneous nodules: Dercum\u2019s disease, a rare variant of lipoma"],"prefix":"10.1136","volume":"16","author":[{"given":"Maddison","family":"Hollands","sequence":"first","affiliation":[{"name":"St John of God Midland Public and Private Hospitals, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleo","family":"Wee","sequence":"additional","affiliation":[{"name":"Curtin Medical School, Curtin University Bentley Campus, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Breidahl","sequence":"additional","affiliation":[{"name":"Perth Radiological Clinic, Subiaco, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-1111","authenticated-orcid":false,"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Curtin Medical School, Curtin University Bentley Campus, Perth, Western Australia, Australia"},{"name":"Medical Education & General Practice, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2025082801013592000_16.8.e254263.1","article-title":"Dercum's disease: A case report of a patient having both type 1 and type 2 Dercum's 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dolorosa)","volume":"33","author":"Cuellar-Barboza","year":"2020","journal-title":"Dermatol Ther"},{"key":"2025082801013592000_16.8.e254263.9","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1526-4637.2011.01101.x","article-title":"Liposuction may reduce pain in Dercum\u2019s disease (Adiposis dolorosa)","volume":"12","author":"Hansson","year":"2011","journal-title":"Pain Med"},{"key":"2025082801013592000_16.8.e254263.10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00296-008-0635-3","article-title":"Dercum\u2019s disease (Lipomatosis dolorosa): successful therapy with Pregabalin and manual Lymphatic drainage and a current overview","volume":"29","author":"Lange","year":"2008","journal-title":"Rheumatol Int"}],"container-title":["BMJ Case 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