{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:11:31Z","timestamp":1776766291818,"version":"3.51.2"},"reference-count":9,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,9,18]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Transient reactive phlebitis (TRP) is a rare adverse event seen with intravenous infusion of medications. It is characterised by the appearance of erythematous cord-like lesions along the superficial veins proximal to the site of infusion. It is rarely seen with drugs such as morphine, rocuronium, eptifibatide, propofol and vancomycin. The exact pathogenesis is not clear; however, certain proposed mechanisms are due to the direct activation of C-nociceptors, activation of the kallikrein-kinin system with bradykinin release, local mediator release or histamine release. Here, we report a case of TRP due to ciprofloxacin infusion.<\/jats:p>","DOI":"10.1136\/bcr-2022-254289","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:45:26Z","timestamp":1696340726000},"page":"e254289","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Transient reactive phlebitis and intravenous ciprofloxacin: Is there an association?"],"prefix":"10.1136","volume":"16","author":[{"given":"Akshay","family":"Rao","sequence":"first","affiliation":[{"name":"General Medicine, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6845-1244","authenticated-orcid":false,"given":"Deena","family":"Patil","sequence":"additional","affiliation":[{"name":"Dermatology, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayashree","family":"Thyagaraj","sequence":"additional","affiliation":[{"name":"General Medicine, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreyank Honnavara","family":"Shankar","sequence":"additional","affiliation":[{"name":"General Medicine, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Balawat","sequence":"additional","affiliation":[{"name":"Dermatology, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"2025082803591820000_16.10.e254289.1","first-page":"132","article-title":"Identification of potentially irritating intravenous medications","volume":"33","author":"Ballesteros-Pe\u00f1a","year":"2022","journal-title":"Enferm Intensiva (Engl Ed)"},{"key":"2025082803591820000_16.10.e254289.2","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819877323"},{"key":"2025082803591820000_16.10.e254289.3","article-title":"Getting under your skin: first reported case of transient reactive phlebitis involving vancomycin infusion therapy","volume":"13","author":"Azimi-Ghomi","year":"2021","journal-title":"Cureus"},{"key":"2025082803591820000_16.10.e254289.4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/jbcpp-2020-0115","article-title":"Ciprofloxacin-induced cutaneous adverse drug events: a systematic review of descriptive studies","volume":"33","author":"Kashyap","year":"2021","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"2025082803591820000_16.10.e254289.5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082803591820000_16.10.e254289.6","first-page":"a707","article-title":"An unusual reaction to IV pethidine\u2014a case report","volume":"7","author":"Krishnan","year":"2014","journal-title":"Br J Med Pract"},{"key":"2025082803591820000_16.10.e254289.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-237273","article-title":"Transient phlebitis: an unusual effect of intravenous diphenhydramine","volume":"13","author":"Manchegowda","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082803591820000_16.10.e254289.8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jpeds.2018.03.045","article-title":"Immediate superficial venous thrombophlebitis associated with intravenous administration of ciprofloxacin","volume":"200","author":"Shah","year":"2018","journal-title":"J Pediatr"},{"key":"2025082803591820000_16.10.e254289.9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.4.533"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-254289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:59:29Z","timestamp":1756378769000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-254289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,3]]},"published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1136\/bcr-2022-254289"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-254289","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}