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We present an interesting case of a young adult male who was diagnosed with primary bone lymphoma of the femur. Interestingly, his initial X-ray imaging revealed no osseous abnormality and subsequent MRI revealed an infiltrating mass. The patient was treated with chemotherapy of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone resulting in complete remission.<\/jats:p>","DOI":"10.1136\/bcr-2022-254291","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T23:35:37Z","timestamp":1689809737000},"page":"e254291","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rare case of primary bone lymphoma of the femur"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-8917","authenticated-orcid":false,"given":"Amy","family":"Kiamos","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Boldig","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Gagadam","sequence":"additional","affiliation":[{"name":"Hospital Medicine, University of Florida Health Science Center, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gujarathi","sequence":"additional","affiliation":[{"name":"Hospital Medicine, University of Florida Health Science Center, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"2025082804124974000_16.7.e254291.1","doi-asserted-by":"crossref","unstructured":"Bindal P , Desai A , Delasos L , et al . 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