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We report a case of an adult male who presented with Brown-S\u00e9quard syndrome and with a positive SARS-CoV-2 nasopharyngeal swab PCR test. Neurological symptoms rapidly resolved after initiation of high-dose methylprednisolone. The findings reported not only contribute to documenting a new presentation of neurological complications associated with SARS-CoV-2 infection but also non-exclusively supports the body of literature suggesting the immune-mediated response to this infection as a mechanism of neuropathogenesis. In this case, COVID-19-related acute myelitis responded to treatment with a short regimen of high-dose glucocorticoids.<\/jats:p>","DOI":"10.1136\/bcr-2022-254496","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T11:50:33Z","timestamp":1707306633000},"page":"e254496","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Parainfectious Brown-S\u00e9quard syndrome associated with COVID-19"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-2132","authenticated-orcid":false,"given":"Lily Ye","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Central Florida College of Medicine, Orlando, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Diem-Trang","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Central Florida 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