{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:15:02Z","timestamp":1784128502803,"version":"3.55.0"},"reference-count":33,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,18]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                  <jats:italic>Apolipoprotein 1<\/jats:italic> (<jats:italic>APOL1<\/jats:italic>) risk variants (G1 and G2) are associated with focal segmental glomerulosclerosis (FSGS) in patients of African ancestry. The prevalence of <jats:italic>APOL1<\/jats:italic> two risk variants is lower in Hispanics and very rare in European and Asian populations. <jats:italic>APOL1<\/jats:italic> two risk variants in donor kidneys is associated with recipient kidney graft loss, however the effect of recipient risk variant in the kidney transplant outcome is unclear. Here, we present a late adolescent male with FSGS and end stage renal disease with one <jats:italic>APOL1<\/jats:italic> risk variant (G2) who had immediate recurrence of FSGS in the post-KT period. There was an excellent response to few sessions of plasmapheresis and Rituximab with no further recurrence of FSGS in the 1\u2009year follow-up period. It needs to be seen whether the recipient <jats:italic>APOL1<\/jats:italic> single risk variant causes increased susceptibility to kidney graft loss on a long run via recurrent or de novo pathologies.<\/jats:p>","DOI":"10.1136\/bcr-2023-254593","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:20:27Z","timestamp":1685532027000},"page":"e254593","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Early recurrence of focal segmental glomerulosclerosis in a kidney transplant recipient with <i>APOL1<\/i> one risk variant"],"prefix":"10.1136","volume":"16","author":[{"given":"Ratna","family":"Acharya","sequence":"first","affiliation":[{"name":"Paediatrics, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-0220","authenticated-orcid":false,"given":"Kiran","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Paediatrics and Nephrology, University of Florida Health, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"2025082710133600000_16.5.e254593.1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.15161219"},{"key":"2025082710133600000_16.5.e254593.2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040388"},{"key":"2025082710133600000_16.5.e254593.3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1600-6143.2011.03513.x","article-title":"The Apol1 gene and allograft survival after kidney transplantation","volume":"11","author":"Reeves-Daniel","year":"2011","journal-title":"American Journal of 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