{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:45:01Z","timestamp":1763037901022,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,4,16]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Gastrointestinal (GI) amyloidosis can be acquired or genetic and is commonly caused by chronic inflammatory illnesses (AA amyloidosis), haematological malignancies (AL amyloidosis) and end-stage renal disease (beta-2 microglobulin amyloidosis). The accumulation of these aberrant proteins disrupts the structures and functions of many organs; the least common of which is the GI tract. GI presentations depend on the type, location and amount of amyloid deposition. Symptoms can range from nausea and vomiting to fatal GI bleeds. Pathological examination of the involved tissue with characteristic green birefringence under polarised light is used to confirm the diagnosis. Patients should be considered for further evaluation to rule out additional organ involvement, notably cardiac and renal. We present a patient with amyloidosis-induced gastroparesis, an under-recognised presentation of systemic amyloidosis in the gastroenterology system.<\/jats:p>","DOI":"10.1136\/bcr-2023-254634","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:10:29Z","timestamp":1683025829000},"page":"e254634","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Gastroparesis: an under-recognised manifestation of systemic amyloidosis"],"prefix":"10.1136","volume":"16","author":[{"given":"Khaled M","family":"Abdullah","sequence":"first","affiliation":[{"name":"Internal Medicine, University of California San Francisco, Fresno, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Alsuraimi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suaka","family":"Kagbo-Kue","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Mayo Clinic, Scottsdale, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Vela","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Mayo Clinic, Scottsdale, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"2025082710062267000_16.5.e254634.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5493"},{"key":"2025082710062267000_16.5.e254634.2","article-title":"Gastrointestinal amyloidosis: review of the literature","volume":"9","author":"Rowe","year":"2017","journal-title":"Cureus"},{"key":"2025082710062267000_16.5.e254634.3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000489297","article-title":"Gastroparesis in a patient with gastric al amyloidosis","volume":"12","author":"Hoscheit","year":"2018","journal-title":"Case Rep Gastroenterol"},{"key":"2025082710062267000_16.5.e254634.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"2025082710062267000_16.5.e254634.5","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"2025082710062267000_16.5.e254634.6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/CLEP.S39981","article-title":"Systemic AA amyloidosis: epidemiology, diagnosis, and management","volume":"6","author":"Real de As\u00faa","year":"2014","journal-title":"Clin Epidemiol"},{"key":"2025082710062267000_16.5.e254634.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01669.x"},{"key":"2025082710062267000_16.5.e254634.8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2214\/ajr.110.2.406","article-title":"Roentgenologic appearance of systemic amyloidosis involving gastrointestinal tract","volume":"110","author":"Legge","year":"1970","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"2025082710062267000_16.5.e254634.9","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.64.755.696"},{"key":"2025082710062267000_16.5.e254634.10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0266-4356(85)90029-4","article-title":"Primary amyloidosis causing macroglossia and respiratory symptoms","volume":"23","author":"Hammersley","year":"1985","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2025082710062267000_16.5.e254634.11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0022-510X(87)90267-X","article-title":"Vagus nerve and celiac ganglion lesions in generalized amyloidosis. A correlative study of familial amyloid polyneuropathy and AL-amyloidosis","volume":"79","author":"Ikeda","year":"1987","journal-title":"J Neurol Sci"},{"key":"2025082710062267000_16.5.e254634.12","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0046-8177(85)80032-0","article-title":"Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and aa (secondary) amyloidosis: diagnostic value of gastric biopsy","volume":"16","author":"Yamada","year":"1985","journal-title":"Hum Pathol"},{"key":"2025082710062267000_16.5.e254634.13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620302"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-254634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:06:30Z","timestamp":1756314390000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-254634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,2]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/bcr-2023-254634"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-254634","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}