{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:48:31Z","timestamp":1757310511472,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,6,25]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Pheochromocytomas are rare tumours originating in chromaf\ufb01n cells, representing 0.1%\u20131% of all secondary hypertension cases. The majority are benign and unilateral, characterised by the production of catecholamines and other neuropeptides. Mainly located in the adrenal gland, they are more frequent between the third and fifth decades of life. Iodine-131 metaiodobenzylguanidine (<jats:sup>131<\/jats:sup>I-MIBG), a radiopharmaceutical agent used for scintigraphic localisation of pheochromocytomas, has been employed to treat malignant pheochromocytomas since 1983 in a few specialised centres around the world. We reviewed our clinical experience in one such case of a young lady who presented with history of abdominal pain, headache and lower back pain. On evaluation, ultrasonography revealed a right adrenal mass and elevated urine vanillylmandelic acid levels. Following surgical resection and histopathological confirmation of pheochromocytoma, MIBG scintigraphy revealed osseous metastases and hence, she underwent <jats:sup>131<\/jats:sup>I-MIBG therapy.<\/jats:p>","DOI":"10.1136\/bcr-2023-254747","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T10:58:28Z","timestamp":1720177108000},"page":"e254747","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term disease-free survival after MIBG therapy for metastatic pheochromocytoma"],"prefix":"10.1136","volume":"17","author":[{"given":"Junita Rachel","family":"John","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital Vellore, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Hephzibah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital Vellore, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nylla","family":"Shanthly","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital Vellore, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regi","family":"Oommen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital Vellore, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"2025082707325659000_17.7.e254747.1","unstructured":"Young WFJ . Endocrine hypertension. In: Melmed S , Polonsky KS , Larsen PR , et al ., eds. Williams Textbook of Endocrinology. 13th edn. Philadelphia: Elsevier, 2016."},{"key":"2025082707325659000_17.7.e254747.2","doi-asserted-by":"crossref","unstructured":"Piccardo A , Foppiani L , Righi S , et al . 131I-MIBG therapy of Malingant neuroblastoma and pheochromocytoma. In: Giovanella L , ed. Nuclear medicine therapy. 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Current consensus on I-131 MIBG therapy. 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