{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:18:37Z","timestamp":1771532317940,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,9,9]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Aspergillosis is a challenging fungal infection. Voriconazole is an antifungal drug belonging to the triazole group, commonly used for treating invasive aspergillosis, <jats:italic>Cryptococcus neoformans<\/jats:italic> and candida infections. We present a case of a man in his late 70s diagnosed with rhino-orbital invasive aspergillosis who developed voriconazole-induced psychosis as an idiosyncratic, adverse drug reaction (ADR); however, he responded to the cessation of intravenous voriconazole and, after starting on an oral antipsychotic, haloperidol. Clinicians need to be cognizant of this rare, idiosyncratic and iatrogenic ADR to voriconazole.<\/jats:p>","DOI":"10.1136\/bcr-2023-254790","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:15:55Z","timestamp":1697026555000},"page":"e254790","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Voriconazole-induced psychosis in rhino-orbital invasive aspergillosis"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-2023","authenticated-orcid":false,"given":"H Swarna","family":"Rekha","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"},{"name":"Department of Psychiatry, NIMHANS, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8624-9965","authenticated-orcid":false,"given":"Sabharisan","family":"Paramasivam","sequence":"additional","affiliation":[{"name":"Department of ENT, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalaiarasi","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of ENT, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"2025082801363039000_16.10.e254790.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)80126-1"},{"key":"2025082801363039000_16.10.e254790.2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645070-00002"},{"key":"2025082801363039000_16.10.e254790.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67490-9"},{"key":"2025082801363039000_16.10.e254790.4","doi-asserted-by":"publisher","DOI":"10.1086\/588844"},{"key":"2025082801363039000_16.10.e254790.5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4103\/0253-7613.157136","article-title":"Voriconazole-induced psychosis in a case of acute myeloid leukemia with febrile neutropenia","volume":"47","author":"Singh","year":"2015","journal-title":"Indian J Pharmacol"},{"key":"2025082801363039000_16.10.e254790.6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0972-6748.57851","article-title":"Understanding delusions","volume":"18","author":"Kiran","year":"2009","journal-title":"Ind Psychiatry J"},{"key":"2025082801363039000_16.10.e254790.7","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-004-3121-1"},{"key":"2025082801363039000_16.10.e254790.8","first-page":"3989070","article-title":"Neurologic adverse events associated with voriconazole therapy: report of two pediatric cases","volume":"2016","author":"Demir","year":"2016","journal-title":"Case Rep Infect Dis"},{"key":"2025082801363039000_16.10.e254790.9","first-page":"1","article-title":"Itraconazole induced psychosis: a case report","volume":"3","author":"Saha","year":"2020","journal-title":"Annals of Psychiatry and Clinical Neuroscience"},{"key":"2025082801363039000_16.10.e254790.10","doi-asserted-by":"crossref","unstructured":"Amadori M . 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