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Despite being a minority, these tumours demonstrate aggressive behaviour resulting in delayed presentations with widespread local invasion. We report a case involving a woman in her 50s who was diagnosed on imaging with a suspected gallbladder malignancy in the community. She proceeded to have a laparoscopic extended cholecystectomy with a cuff of segment 4b and 5 liver resection and cystic node sampling revealing a T3N1 lesion which on further recommendation by the multidisciplinary team proceeded to have an open portal lymphadenectomy yielding another positive lymph node. This case report highlights the dilemmas encountered in the management of this rare histological subtype in the absence of well-defined treatment algorithm and evolving guidelines.<\/jats:p>","DOI":"10.1136\/bcr-2023-254883","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:01:19Z","timestamp":1685095279000},"page":"e254883","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Adenosquamous carcinoma of the gallbladder: a rare entity and dilemmas in its management"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-0791","authenticated-orcid":false,"given":"Muhammed Ali","family":"Zishan","sequence":"first","affiliation":[{"name":"General Surgery, Redcliffe Hospital, Redcliffe, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Li","family":"Tee","sequence":"additional","affiliation":[{"name":"General Surgery, Redcliffe Hospital, Redcliffe, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"2025082707322193000_16.5.e254883.1","unstructured":"Mollah T , Chia M , Wang LC . 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Adenosquamous carcinoma of gallbladder associated with biliopancreatic maljunction and Todani 1c choledochal cyst: a case report. 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