{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:14Z","timestamp":1756339394564,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,7,7]]},"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Intravitreal methotrexate injection (400\u2009\u00b5g\/0.1\u2009mL) is the current mainstay for managing vitreoretinal lymphoma. Various complications associated with intravitreal methotrexate are cataract, keratopathy, maculopathy, sterile endophthalmitis, optic atrophy, vitreous haemorrhage, etc. The most common adverse effect of intravitreal methotrexate is keratopathy occurring in more than half of cases. The severity may range from diffuse punctate keratopathy to severe epitheliopathy leading to photophobia, pain, visual blurring, epiphora, etc. This may become a reason for reduced compliance with treatment. The management of these complications includes oral folic acid, topical folinic acid supplementations and reduced frequency or cessation of methotrexate intravitreal injections. Here, we report a simple method of eyewash in a large amount of balanced salt solution after the intravitreal injection procedure to reduce the severity of keratopathy, which helped the patient tolerate the treatment.<\/jats:p>","DOI":"10.1136\/bcr-2023-255096","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T23:35:39Z","timestamp":1689809739000},"page":"e255096","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Eyewash with balanced salt solution after intravitreal methotrexate injection in a case of vitreoretinal lymphoma: a simple but effective way to prevent ocular surface toxicity"],"prefix":"10.1136","volume":"16","author":[{"given":"Bruttendu","family":"Moharana","sequence":"first","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sucheta","family":"Parija","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmugasundaram","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadarshini","family":"Mishra","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Orissa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"2025082701135643000_16.7.e255096.1","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-020-01464-3","article-title":"Reduced frequency of intravitreal methotrexate injection LOWERS the risk of keratopathy in vitreoretinal lymphoma patients","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"2025082701135643000_16.7.e255096.2","doi-asserted-by":"crossref","unstructured":"Sahay P , Maharana PK , Temkar S , et al . Corneal epithelial toxicity with intravitreal methotrexate in a case of B-cell lymphoma with ocular involvement. BMJ Case Reports 2018:bcr\u20132018 doi:10.1136\/bcr-2018-226005","DOI":"10.1136\/bcr-2018-226005"},{"key":"2025082701135643000_16.7.e255096.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01125-9"},{"key":"2025082701135643000_16.7.e255096.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.127928"},{"key":"2025082701135643000_16.7.e255096.5","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310000-00008"},{"key":"2025082701135643000_16.7.e255096.6","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9082672","article-title":"Corneal epithelial toxicity after intravitreal methotrexate injection for vitreoretinal lymphoma: clinical and in vitro studies","volume":"9","author":"Jeong","year":"2020","journal-title":"J Clin Med"},{"key":"2025082701135643000_16.7.e255096.7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000098"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-255096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:14:03Z","timestamp":1756282443000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-255096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7,19]]},"published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1136\/bcr-2023-255096"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-255096","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}