{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:59:07Z","timestamp":1763564347311,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,4,6]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Olmesartan is an angiotensin II receptor blocker licensed for the treatment of hypertension. It can cause a sprue-like enteropathy (SLE), characterised by chronic diarrhoea, weight loss and villous atrophy. Transiently raised anti-tissue transglutaminase (ATTG) antibody has also been rarely reported in the literature.<\/jats:p>\n               <jats:p>We describe the case of a woman in her mid-50s, who presented with a history of intermittent loose stools over 1 year, associated with significant weight loss. She had two marginally raised serum ATTG antibody tests during her work-up.<\/jats:p>\n               <jats:p>After extensive investigations, she was diagnosed with olmesartan-induced enteropathy. On subsequent follow-up, her symptoms had resolved with cessation of her olmesartan therapy.<\/jats:p>\n               <jats:p>This case adds to existing literature, highlighting the importance of considering olmesartan as a possible differential diagnosis for SLE. It also reports the presence of a raised ATTG antibody which is infrequently reported in this context.<\/jats:p>","DOI":"10.1136\/bcr-2023-255407","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:00:15Z","timestamp":1715000415000},"page":"e255407","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic diarrhoea, weight loss and a positive anti-tissue transglutaminase antibody: A case report of olmesartan-induced enteropathy"],"prefix":"10.1136","volume":"17","author":[{"given":"Rachel","family":"Sheppard","sequence":"first","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Evanson","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Campbell","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Shand","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"2025082709311212000_17.5.e255407.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.06.003"},{"key":"2025082709311212000_17.5.e255407.2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/gastro\/goz019","article-title":"Angiotensin II receptor blockers and gastrointestinal adverse events of resembling sprue-like Enteropathy: a systematic review","volume":"7","author":"Kamal","year":"2019","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"2025082709311212000_17.5.e255407.3","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/apt.14518","article-title":"Use of Olmesartan and Enteropathy outcomes: a multi-database study","volume":"47","author":"Dong","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"2025082709311212000_17.5.e255407.4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309690"},{"key":"2025082709311212000_17.5.e255407.5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3904\/kjim.2017.002","article-title":"Olmesartan is not associated with the risk of Enteropathy: a Korean nationwide observational cohort study","volume":"34","author":"You","year":"2019","journal-title":"Korean J Intern Med"},{"key":"2025082709311212000_17.5.e255407.6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/pds.4402","article-title":"Severe intestinal Malabsorption associated with ACE inhibitor or angiotensin receptor blocker treatment. An observational cohort study in Germany and Italy","volume":"27","author":"Malfertheiner","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2025082709311212000_17.5.e255407.7","unstructured":"National Institute for Health and Care Excellence . Hypertension in adults: diagnosis and management. London: NICE; 2022. 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