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To the authors\u2019 knowledge, this is the first case of amelanotic melanoma presenting in a patient with trisomy 21 and the fifth case of melanoma overall reported in a patient with trisomy 21.This case highlights the need for specialist referral of all new skin lesions where the diagnosis is unclear.<\/jats:p>","DOI":"10.1136\/bcr-2023-255503","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T08:00:37Z","timestamp":1692432037000},"page":"e255503","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Amelanotic melanoma in a patient with trisomy 21: clinical and dermoscopic presentation"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-2048","authenticated-orcid":false,"given":"Marion","family":"Leahy","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Reidy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Laing","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Galway, Galway, Ireland"},{"name":"National University of Ireland Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"2025082700230062000_16.8.e255503.1","doi-asserted-by":"crossref","DOI":"10.1097\/00008390-200404000-00065","article-title":"Amelanotic\/hypomelanotic melanoma: clinical and dermoscopic features","volume":"14","author":"Pizzichetta","year":"2004","journal-title":"Melanoma Research"},{"key":"2025082700230062000_16.8.e255503.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01808.x"},{"key":"2025082700230062000_16.8.e255503.3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1346-8138.1993.tb03831.x","article-title":"Acral lentiginous melanoma associated with down\u2019s syndrome","volume":"20","author":"Nakano","year":"1993","journal-title":"J Dermatol"},{"key":"2025082700230062000_16.8.e255503.4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0093-3619(08)70256-9","article-title":"Malignant melanoma in childhood and adolescence: report of 13 cases","volume":"2006","author":"Raimer","year":"2006","journal-title":"Yearbook of Dermatology and Dermatologic Surgery"},{"key":"2025082700230062000_16.8.e255503.5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1525-1470.2012.01764.x","article-title":"Adolescent girl with down syndrome and lumbar cutaneous melanoma","volume":"31","author":"Satg\u00e9","year":"2014","journal-title":"Pediatr Dermatol"},{"key":"2025082700230062000_16.8.e255503.6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/j.jfas.2012.01.013","article-title":"Subungual melanoma of the great toe in a hispanic male with down syndrome: a case report and review of the literature","volume":"51","author":"Kwok-Oleksy","year":"2012","journal-title":"J Foot Ankle Surg"},{"key":"2025082700230062000_16.8.e255503.7","doi-asserted-by":"crossref","unstructured":"Nayar A . 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