{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:17Z","timestamp":1756425737638,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,11,12]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Carcinoid heart disease is a unique and serious cardiac complication of the neuroendocrine tumour that affects the right side of the heart, especially the tricuspid and pulmonic valves, eventually causing right heart failure. We present a middle-aged man with a history of well-differentiated neuroendocrine tumours of the small intestine with extensive metastases to the liver, mesentery and spine who is receiving monthly octreotide therapy. He presented with generalised fatigue, severe ascites and worsening dyspnoea. Both the transthoracic echocardiography and transoesophageal echocardiography revealed severe tricuspid and pulmonic regurgitations. He was considered a poor surgical candidate, underwent transcatheter pulmonic valve replacement with two bioprosthetic valve-in-valve implantations and was discharged in a stable condition.<\/jats:p>","DOI":"10.1136\/bcr-2023-255518","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:51:51Z","timestamp":1701867111000},"page":"e255518","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Carcinoid heart disease: a potentially fatal complication of carcinoid syndrome"],"prefix":"10.1136","volume":"16","author":[{"given":"Mustafa","family":"Bdiwi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Ramaseshan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Uddin","sequence":"additional","affiliation":[{"name":"Cardiology\/Department of Internal medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mishita","family":"Goel","sequence":"additional","affiliation":[{"name":"Cardiology\/Department of Internal medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saman","family":"Razzaq","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alrayyashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Afonso","sequence":"additional","affiliation":[{"name":"Cardiology\/Department of Internal medicine, Wayne State University\/ Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"2025082722434747000_16.12.e255518.1","first-page":"497","article-title":"Carcinoid heart disease: A guide for Clinicians","volume":"37","author":"Perry","year":"2019","journal-title":"Cardiol Clin"},{"key":"2025082722434747000_16.12.e255518.2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.14503\/THIJ-17-6562","article-title":"Carcinoid heart disease: review of current knowledge","volume":"46","author":"Ram","year":"2019","journal-title":"Tex Heart Inst J"},{"key":"2025082722434747000_16.12.e255518.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.4.1188"},{"key":"2025082722434747000_16.12.e255518.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.12.030"},{"key":"2025082722434747000_16.12.e255518.5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ando.2020.12.007","article-title":"Managing Carcinoid heart disease in patients with Neuroendocrine tumors","volume":"82","author":"Koffas","year":"2021","journal-title":"Ann Endocrinol (Paris)"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-255518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:43:55Z","timestamp":1756359835000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-255518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,6]]},"published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1136\/bcr-2023-255518"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-255518","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}