{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:10:02Z","timestamp":1756314602525,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,2]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Congenital nephrotic syndrome (CNS) is a rare clinical syndrome with a constellation of proteinuria, hypoalbuminaemia and oedema, presenting within 3\u2009months of birth. We present a rare case of neonatal nephrotic syndrome with a probable sepsis induced aetiology. The neonate was referred at day of life 15 with <jats:italic>Klebsiella pneumonia<\/jats:italic> sepsis and anasarca. On investigation, the patient had nephrotic range proteinuria, hypoalbuminaemia, generalised anasarca and ascites. The neonate was started on broad-spectrum antibiotics and furosemide. Genetic and other secondary causes of CNS were ruled out. With supportive management and resolution of sepsis, the neonate improved. This case highlights the rare cause of sepsis-induced nephrotic syndrome (NS), which required only supportive treatment without the need for aggressive management of CNS.<\/jats:p>","DOI":"10.1136\/bcr-2023-255584","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T02:05:36Z","timestamp":1706148336000},"page":"e255584","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal nephrotic syndrome: all is not gloomy"],"prefix":"10.1136","volume":"17","author":[{"given":"Chinmay","family":"Chetan","sequence":"first","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-4696","authenticated-orcid":false,"given":"Saikat","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"2025082709392826000_17.1.e255584.1","first-page":"740","article-title":"Syndrome de Nephrose Lipoidique Congenitale","volume":"62","author":"Gautier","year":"1942","journal-title":"Rev Med Suisse Rom"},{"key":"2025082709392826000_17.1.e255584.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00857534"},{"key":"2025082709392826000_17.1.e255584.3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41581-020-00384-1","article-title":"Management of congenital nephrotic syndrome: consensus recommendations of the Erknet-ESPN working group","volume":"17","author":"Boyer","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"2025082709392826000_17.1.e255584.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.05.009"},{"key":"2025082709392826000_17.1.e255584.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2164"},{"key":"2025082709392826000_17.1.e255584.6","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00467-020-04578-4","article-title":"Congenital nephrotic syndrome: is early aggressive treatment needed? Yes","volume":"35","author":"H\u00f6ltt\u00e4","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"2025082709392826000_17.1.e255584.7","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2019.00341","article-title":"Analysis of 14 patients with congenital nephrotic syndrome","volume":"7","author":"Chen","year":"2019","journal-title":"Front Pediatr"},{"key":"2025082709392826000_17.1.e255584.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.3.237"},{"key":"2025082709392826000_17.1.e255584.9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-3476(74)80117-4","article-title":"Congenital nephrotic syndrome associated with congenital Toxoplasmosis","volume":"85","author":"Shahin","year":"1974","journal-title":"J Pediatr"},{"key":"2025082709392826000_17.1.e255584.10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12519-016-0009-y","article-title":"The etiology of congenital nephrotic syndrome: Current status and challenges","volume":"12","author":"Wang","year":"2016","journal-title":"World J Pediatr"},{"key":"2025082709392826000_17.1.e255584.11","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.580178","article-title":"Case report: CMV-associated congenital nephrotic syndrome","volume":"8","author":"Jacob","year":"2020","journal-title":"Front Pediatr"},{"key":"2025082709392826000_17.1.e255584.12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2147\/PHMT.S193684","article-title":"Diagnostic and management challenges in congenital nephrotic syndrome","volume":"10","author":"Reynolds","year":"2019","journal-title":"Pediatric Health Med Ther"},{"key":"2025082709392826000_17.1.e255584.13","doi-asserted-by":"crossref","unstructured":"Jalanko H , Jahnukainen T , Ng KH . 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