{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:40:02Z","timestamp":1756377602328,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,12,5]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>A woman 12 weeks and 3\u2009days pregnant was referred to the emergency department with significant hypertension which, despite aggressive medical management, remained uncontrolled. Markedly elevated levels of renin and aldosterone beyond what is typical in early pregnancy were present, which together with the finding of a right ovarian cyst pointed to the possible diagnosis of an extrarenal reninoma.and the decision was made to perform a right-sided oophorectomy at 16 weeks gestation. Histology demonstrated a staining pattern most consistent with a steroid cell tumour leading to the diagnosis of refractory hypertension secondary to an ovarian steroid cell tumour. Post oophorectomy blood biochemistry rapidly returned to normal, and our patient\u2019s hypertension slowly resolved allowing for a large reduction in antihypertensive agent requirements and a successful pregnancy outcome.<\/jats:p>","DOI":"10.1136\/bcr-2023-255716","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T13:15:11Z","timestamp":1703078111000},"page":"e255716","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Rare case of steroid cell tumour presenting as resistant hypertension in early pregnancy"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-7613","authenticated-orcid":false,"given":"Maura","family":"Hannon","sequence":"first","affiliation":[{"name":"Obstetrics and Gynacology, Cork University Maternity Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D","family":"Plant","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Cork University Hospital, Cork, Cork, Ireland"},{"name":"University College Cork College of Medicine and Health, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noirin E","family":"Russell","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynacology, Cork University Maternity Hospital, Cork, Ireland"},{"name":"University College Cork College of Medicine and Health, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"2025082803013505000_16.12.e255716.1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1148\/radiographics.18.6.9821198","article-title":"Sex cord-Stromal and steroid cell tumors of the ovary","volume":"18","author":"Outwater","year":"1998","journal-title":"RadioGraphics"},{"key":"2025082803013505000_16.12.e255716.2","doi-asserted-by":"crossref","unstructured":"Alves P , S\u00e1 I , Brito M , et al . An early diagnosis of an ovarian steroid cell tumor not otherwise specified in a woman. Case Rep Obstet Gynecol 2019. doi:10.1155\/2019\/2537480","DOI":"10.1155\/2019\/2537480"},{"key":"2025082803013505000_16.12.e255716.3","doi-asserted-by":"crossref","unstructured":"Bhagat R , Bodal VK , Gupta N , et al . Steroid cell tumour of ovary \u2013 A rare case report. JCDR 2016. doi:10.7860\/JCDR\/2016\/15767.8556","DOI":"10.7860\/JCDR\/2016\/15767.8556"},{"key":"2025082803013505000_16.12.e255716.4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/gye.16.3.213.216","article-title":"Ovarian steroid cell tumor and a contralateral ovarian thecoma in a postmenopausal woman with severe hyperandrogenism","volume":"16","author":"Cserepes","year":"2002","journal-title":"Gynecol Endocrinol"},{"key":"2025082803013505000_16.12.e255716.5","doi-asserted-by":"crossref","unstructured":"Tan EC , Khong CC , Bhutia K . A rare case of steroid cell tumor, not otherwise specified (NOS), of the ovary in a young woman. Case Rep Obstet Gynecol 2019. doi:10.1155\/2019\/4375839","DOI":"10.1155\/2019\/4375839"},{"key":"2025082803013505000_16.12.e255716.6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198711000-00002"},{"key":"2025082803013505000_16.12.e255716.7","doi-asserted-by":"crossref","unstructured":"Weishaupt J , Herbst U . Steroid cell tumour in pregnancy: reflection on a rare case and review of the literature. Case Rep Obstet Gynecol 2020. doi:10.1155\/2020\/1817042","DOI":"10.1155\/2020\/1817042"},{"key":"2025082803013505000_16.12.e255716.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.091"},{"key":"2025082803013505000_16.12.e255716.9","first-page":"e168","article-title":"Renin-Secreting ovarian adult granulosa cell tumor in a patient with new-onset hypertension and hypokalemia","volume":"5","author":"Karaman","year":"2019","journal-title":"AACE Clin Case Rep"},{"key":"2025082803013505000_16.12.e255716.10","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.01.012"},{"key":"2025082803013505000_16.12.e255716.11","doi-asserted-by":"crossref","unstructured":"Lumbers ER . Chapter 10 - the physiological roles of the renin-angiotensin aldosterone system and vasopressin in human pregnancy. In: Kovacs CS , Deal CL , eds. Maternal-Fetal and Neonatal Endocrinology [Internet]. Academic Press, 2020: 129\u201345. 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