{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:22:52Z","timestamp":1787163772890,"version":"build-2736575974"},"reference-count":8,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,2,28]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had Bblood group 0 and Rrhesus negative. The baby was noticed to have jaundice on day one1 of life accompanied by generalised petechiae on the face and upper chest. A full blood picture revealed severe anaemia and severe thrombocytopaenia and HSV 1\/2 IgM was positive. MRI of the brain showed multiple extensive haemorrhagic lesions on the frontal-temporal regions.<\/jats:p>","DOI":"10.1136\/bcr-2023-255822","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T13:30:14Z","timestamp":1709904614000},"page":"e255822","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal herpes simplex virus encephalitis with intracranial bleeding in a newborn baby with concurrent rhesus incompatibility"],"prefix":"10.1136","volume":"17","author":[{"given":"Pascal","family":"Clemence","sequence":"first","affiliation":[{"name":"Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haika","family":"Mariki","sequence":"additional","affiliation":[{"name":"Pediatrics, Muhimbili National Hospital, Dar es Salaam, Tanzania, United Republic of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Mkony","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Muhimbili National Hospital, Dar es Salaam, Tanzania, United Republic of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-6408","authenticated-orcid":false,"given":"Karim Premji","family":"Manji","sequence":"additional","affiliation":[{"name":"Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"2025082804331275000_17.3.e255822.1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.clp.2021.03.003","article-title":"Neonatal herpes simplex virus disease: updates and continued challenges","volume":"48","author":"Samies","year":"2021","journal-title":"Clin Perinatol"},{"key":"2025082804331275000_17.3.e255822.2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.06.100257"},{"key":"2025082804331275000_17.3.e255822.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bcr-2022-252627","article-title":"Neonatal herpes simplex presenting as a zosteriform eruption","volume":"16","author":"Anderson","year":"2023","journal-title":"BMJ Case Rep"},{"key":"2025082804331275000_17.3.e255822.4","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-11-1"},{"key":"2025082804331275000_17.3.e255822.5","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100002419"},{"key":"2025082804331275000_17.3.e255822.6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jamaneurol.2014.2376","article-title":"Encephalitis of unclear origin diagnosed by brain biopsy: a diagnostic challenge","volume":"72","author":"Gelfand","year":"2015","journal-title":"JAMA Neurol"},{"key":"2025082804331275000_17.3.e255822.7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0887-8994(02)00428-9","article-title":"Intracranial hemorrhage in herpes simplex encephalitis: an unusual presentation","volume":"27","author":"Erdem","year":"2002","journal-title":"Pediatr Neurol"},{"key":"2025082804331275000_17.3.e255822.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/oalib.1101280","article-title":"Late onset neonatal herpes encephalitis: a case-based CNS complication and neurological outcome","volume":"02","author":"Gupta","year":"2015","journal-title":"OALib"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-255822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:33:18Z","timestamp":1756380798000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-255822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,8]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bcr-2023-255822"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-255822","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}