{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:21:27Z","timestamp":1793676087762,"version":"4.5.1"},"reference-count":40,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,4]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Mucoepidermoid cancer (MEC) is extremely rare in the palatine tonsil with only three adequately described cases in the literature.<\/jats:p>\n               <jats:p>We describe a woman in her late 70s with vague pharyngeal discomfort who underwent tonsillectomy, lymph node dissection of the neck and radiotherapy for MEC with loco-regional lymph node metastasis of the palatine tonsil. To confirm this extremely rare diagnosis and to gain deeper insight in the molecular oncogenesis, an extensive molecular study including next-generation sequencing and immunohistochemistry was performed. Immunoreactivity for p16 protein and real-time PCR showed high-risk oncogenic human papillomavirus 16 DNA and mutations in the BRAF, BARD and DNMT3A genes. Tumour mutational burden was low. After a follow-up of 7 years the patient is still alive and well without any residual or disseminated disease.<\/jats:p>","DOI":"10.1136\/bcr-2023-255864","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:06:22Z","timestamp":1705064782000},"page":"e255864","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Very rare tumour of the palatine tonsil: a molecular approach"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-6355","authenticated-orcid":false,"given":"Maaike","family":"Ramael","sequence":"first","affiliation":[{"name":"University of Antwerp Faculty of Medicine and Health Sciences, Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Van Steelandt","sequence":"additional","affiliation":[{"name":"General Hospital AZ Herentals, Herentals, 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