{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:19Z","timestamp":1756275019274,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,8,17]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Cutaneous lymphoproliferative disorders include cutaneous manifestations of systemic B-cell or T-cell lymphoma and primary cutaneous lymphomas. Primary cutaneous B-cell lymphomas are subcategorised into four groups: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle centre lymphoma, primary cutaneous diffuse large B-cell lymphoma, leg-type and EBV-positive mucocutaneous tumour. Each of these cutaneous lymphoproliferative disorders has unique clinical and pathological features necessitating biopsy and staging to establish proper treatment. We present a case of PCMZL manifesting as secondary chilblains of the toes that was diagnosed with punch skin biopsy. The patient\u2019s chilblains resolved with rituximab. This case underscores the importance of considering PCMZL and other cutaneous lymphoproliferative disorders in patients with dermatological manifestations and wounds refractory to first-line treatment.<\/jats:p>","DOI":"10.1136\/bcr-2023-255894","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:41:06Z","timestamp":1693183266000},"page":"e255894","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary cutaneous marginal zone lymphoma presenting with secondary chilblains of the toes"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-7209","authenticated-orcid":false,"given":"Ali Zagham","family":"Nasir","sequence":"first","affiliation":[{"name":"Internal Medicine Residency, Trinity Health Saint Mary's - Grand Rapids, Grand Rapids, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan Scott","family":"Burmeister","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency, Trinity Health Saint Mary's - Grand Rapids, Grand Rapids, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.1","DOI":"10.1182\/blood-2018-11-881268"},{"key":"2025082622432375000_16.8.e255894.2","doi-asserted-by":"crossref","DOI":"10.21037\/aol-20-28","article-title":"Epidemiology of marginal zone lymphoma","volume":"5","author":"Cerhan","year":"2021","journal-title":"Ann Lymphoma"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.3","DOI":"10.1182\/blood-2008-10-184168"},{"key":"2025082622432375000_16.8.e255894.4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jaad.2013.04.047","article-title":"Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients","volume":"69","author":"Servitje","year":"2013","journal-title":"J Am Acad Dermatol"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.5","DOI":"10.1001\/archderm.141.9.1139"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.6","DOI":"10.1200\/JCO.2005.03.0395"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.7","DOI":"10.1016\/j.critrevonc.2009.09.003"},{"key":"2025082622432375000_16.8.e255894.8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.23736\/S0392-0488.17.05670-X","article-title":"Primary cutaneous B-cell lymphoma: narrative review of the literature","volume":"154","author":"Grandi","year":"2019","journal-title":"G Ital Dermatol Venereol"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.9","DOI":"10.1053\/j.semdp.2016.11.007"},{"doi-asserted-by":"publisher","key":"2025082622432375000_16.8.e255894.10","DOI":"10.1097\/00005792-200105000-00004"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-255894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:43:28Z","timestamp":1756273408000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-255894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,27]]},"published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1136\/bcr-2023-255894"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-255894","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,8]]}}}