{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:20:23Z","timestamp":1778754023546,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,8,14]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly presenting as disseminated invasive fungal infection with cerebrorhino-orbital involvement in an immunocompromised patient. Infections are most commonly caused by direct implantation of spores with localised angioinvasion. Haematogenous spread is rare, with most cases secondary to haematological malignancies or intravenous drug use. Coinfection with mucormycosis and aspergillosis portends a poor prognosis, with a high mortality rate. Thus, prompt recognition and intervention are crucial to prevent poor outcomes. In this unique case report, we describe a case of isolated cerebral mucormycosis and aspergillosis coinfection, not previously reported in literature.<\/jats:p>","DOI":"10.1136\/bcr-2023-255909","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:41:09Z","timestamp":1693183269000},"page":"e255909","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-0943","authenticated-orcid":false,"given":"George","family":"Sun","sequence":"first","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Weiss","sequence":"additional","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Zhao","sequence":"additional","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Silver","sequence":"additional","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"DeMaio","sequence":"additional","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-0274","authenticated-orcid":false,"given":"Sara","family":"Dehbashi","sequence":"additional","affiliation":[{"name":"Neurology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"2025082801551992000_16.8.e255909.1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s11046-016-0021-8","article-title":"Combined orofacial Aspergillosis and Mucormycosis: fatal complication of a recurrent Paediatric glioma-case report and review of literature","volume":"181","author":"Chermetz","year":"2016","journal-title":"Mycopathologia"},{"key":"2025082801551992000_16.8.e255909.2","doi-asserted-by":"crossref","first-page":"104616","DOI":"10.1016\/j.micpath.2020.104616","article-title":"Distribution of invasive fungal infections: molecular epidemiology, etiology, clinical conditions, diagnosis and risk factors: a 3-year experience with 490 patients under intensive care","volume":"152","author":"Borjian Boroujeni","year":"2021","journal-title":"Microb Pathog"},{"key":"2025082801551992000_16.8.e255909.3","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy187"},{"key":"2025082801551992000_16.8.e255909.4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1439-0507.1996.tb00507.x","article-title":"Disseminated Aspergillosis and Mucormycosis. 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