{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:01Z","timestamp":1756275001918,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,1,15]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Lisinopril is an ACE inhibitor commonly used in the treatment of cardiovascular and renal disease. Rarely, ACE inhibitors have been associated with cholestatic jaundice and hepatitis, with potential risk of fulminant hepatic failure if continued. There is limited information available regarding the risk of hepatic failure secondary to lisinopril use, with a handful of case reports demonstrating drug-induced liver injury at varying time scales from drug initiation. In this case, we present a man with symptoms of cholestatic jaundice, a blistering skin rash and flare of chronic plaque psoriasis, 27 months after lisinopril initiation for hypertension. Biochemical, serological and radiological investigations of an alternative cause for his jaundice were unremarkable. Cessation of lisinopril led to a rapid and sustained improvement in liver biochemistry and a significant improvement in his chronic plaque psoriasis.<\/jats:p>","DOI":"10.1136\/bcr-2023-256317","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T12:45:44Z","timestamp":1706013944000},"page":"e256317","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Delayed drug-induced liver injury (DILI) and flare of chronic plaque psoriasis secondary to lisinopril use"],"prefix":"10.1136","volume":"17","author":[{"given":"Georgeina L","family":"Jarman","sequence":"first","affiliation":[{"name":"Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwilym J","family":"Webb","sequence":"additional","affiliation":[{"name":"Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"2025082622450716000_17.1.e256317.1","unstructured":"NHS Business Services Authority . Prescription cost analysis, England 2021\/22. 2022. Available: https:\/\/nhsbsa-opendata.s3.eu-west-2.amazonaws.com\/pca\/pca_summary_narrative_2021_22_v001.html [Accessed 2 May 2023]."},{"key":"2025082622450716000_17.1.e256317.2","unstructured":"Electronic medicines compendium 2020 . Lisinopril summary of product characteristics (Smpc). Datapharm Ltd, Electronic Medicines Compendium; 2020. Available: https:\/\/www.medicines.org.uk\/emc\/product\/7144\/smpc#gref [Accessed May 2023]."},{"key":"2025082622450716000_17.1.e256317.3","doi-asserted-by":"crossref","unstructured":"Al-Rifaie A , Khan MA , Ali A , et al . Lisinopril-induced liver injury: an unusual presentation and literature review. Eur J Case Rep Intern Med 2020;7. doi:10.12890\/2020_001600","DOI":"10.12890\/2020_001600"},{"key":"2025082622450716000_17.1.e256317.4","doi-asserted-by":"crossref","unstructured":"Song G , Kim JY , Yoon HY , et al . A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence. Sci Rep 2021;11. doi:10.1038\/s41598-021-89490-z","DOI":"10.1038\/s41598-021-89490-z"},{"key":"2025082622450716000_17.1.e256317.5","unstructured":"Livertox: RUCAM causality assessment [Internet]. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548272\/bin\/livertoxrucamv5.pdf [Accessed 28 Aug 2023]."},{"key":"2025082622450716000_17.1.e256317.6","unstructured":"Livertox: clinical and research information on drug-induced liver injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Doxycycline; 2019. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548353 [Accessed 2 May 2023]."},{"key":"2025082622450716000_17.1.e256317.7","unstructured":"Livertox: clinical and research information on drug-induced liver injury [Internet]. Bethesda (MD): National Institute of diabetes and digestive and kidney diseases; 2012-Acyclovir. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548548 [Accessed 2 May 2023]."},{"key":"2025082622450716000_17.1.e256317.8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272786","article-title":"A logistic regression model based on inpatient health records to predict drug-induced liver injury caused by ramipril\u2014an angiotensin-converting enzyme inhibitor","volume":"17","author":"Thi Thu","year":"2022","journal-title":"PLoS One"},{"key":"2025082622450716000_17.1.e256317.9","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt090"},{"key":"2025082622450716000_17.1.e256317.10","unstructured":"Livertox: clinical and research information on drug-induced liver injury [Internet]. Bethesda (MD): National Institute of diabetes and digestive and kidney diseases; 2012-Lisinopril. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548860 [Accessed 19 Oct 2023]."},{"key":"2025082622450716000_17.1.e256317.11","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1038\/s41598-021-89490-z","article-title":"A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence","volume":"11","author":"Song","year":"2021","journal-title":"Sci Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:45:14Z","timestamp":1756273514000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,23]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1136\/bcr-2023-256317"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256317","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}