{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:43:05Z","timestamp":1765438985746,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,8,19]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>A middle-aged man presented with inferior wall ST-elevation myocardial infarction and underwent primary percutaneous coronary intervention with tirofiban administered due to extensive thrombus. He developed sudden-onset dyspnoea, bilateral crepitations, haemoptysis, desaturation and hypotension an hour after starting tirofiban infusion. The tirofiban, antiplatelet medications and heparin were stopped immediately. Chest X-ray showed patchy opacities in the left upper, middle and lower zones. High-resolution CT showed confluent areas of consolidation with surrounding ground glass opacities and interlobular septal thickening (crazy pavement appearance) representing diffuse alveolar haemorrhage (DAH). He was managed with inotropes, non-invasive ventilation and intravenous furosemide. He was asymptomatic with complete resolution of lung opacities in chest X-ray done 2 months follow-up. DAH is a rare but potentially life-threatening complication which is often misidentified with other respiratory syndromes. Treatment includes stopping tirofiban and anticoagulant medication, blood transfusion, and institution of mechanical ventilation.<\/jats:p>","DOI":"10.1136\/bcr-2023-256335","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T22:30:39Z","timestamp":1724970639000},"page":"e256335","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Tirofiban-induced diffuse alveolar haemorrhage"],"prefix":"10.1136","volume":"17","author":[{"given":"Bryan","family":"Sebastian","sequence":"first","affiliation":[{"name":"Cardiology, Aster MIMS Hospital, Kannur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayan","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Cardiology, Aster MIMS Hospital, Kannur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Placid","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Cardiology, Aster MIMS Hospital, Kannur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2025082707340997000_17.8.e256335.1","first-page":"186","article-title":"Use of platelet glycoprotein IIb\/IIIa inhibitors and spontaneous pulmonary hemorrhage","volume":"15","author":"Ali","year":"2003","journal-title":"J Invasive Cardiol"},{"key":"2025082707340997000_17.8.e256335.2","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2013.74.4.151"},{"key":"2025082707340997000_17.8.e256335.3","unstructured":"Lara AR , Frankel SK , Schwarz MI . Diffuse Alveolar Haemorrhage, Interstitial Lung Disease (5th Ed). Shelton, CT, USA: People\u2019s Medical Publishing House, 2011."},{"key":"2025082707340997000_17.8.e256335.4","doi-asserted-by":"crossref","unstructured":"Collard HR , King TE , Schwarz MI . Diffuse Alveolar Hemorrhage and Rare Infiltrative Disorders of the Lung. New York: Murray & Nadel\u2019s Textbook of Respiratory Medicine (6th), Elsevier, 2016.","DOI":"10.1016\/B978-1-4557-3383-5.00067-1"},{"key":"2025082707340997000_17.8.e256335.5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijcard.2016.01.020","article-title":"Diffused alveolar hemorrhage: A rare and severe complication of tirofiban-induced thrombocytopenia","volume":"206","author":"Zhou","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025082707340997000_17.8.e256335.6","first-page":"753","article-title":"A misleading diagnosis in acute coronary syndrome: tirofiban-induced alveolar hemorrhage","volume":"43","author":"\u015earl\u0131","year":"2015","journal-title":"Turk Kardiyol Dern Ars"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2023-256335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:34:19Z","timestamp":1756305259000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2023-256335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":6,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,29]]},"published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1136\/bcr-2023-256335"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2023-256335","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}